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AIRE Antibody

AIRE Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameAIRE Primary Polyclonal Antibody
Also known asAIRE PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenAIRE
SpecificityThis is a highly specific antibody against AIRE
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human AIRE
Gene ID number326
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen AIRE expression in the thymus is confined to the medulla and the cortico-medullary junction, AIRE is expressed in the medullary epithelial cells and monocyte-dendritic cells of the thymus, AIRE is induced by developing early thymocytes and is associated with the correct establishment of a regular thymic environment, AIRE is located in microtubular structures of the cyto-skeleton and in discrete nuclear dots resembling ND10 nuclear bodies, AIRE mutations in APECED patients may affect thymic T cell selection and the formation of self-tolerance, AIRE regulates thymic architecture via transcriptional control of downstream target genes, At the cellular level, In adult tissue, encodes the transcriptional activator AIRE, fetal liver and lymph nodes, where it is modulated by thymocytes undergoing negative selection, which is defective in the hereditary auto-immune disease APECED, with lower expression in the spleen, The autoimmune regulator gene
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names AIRE, AIRE1, AIRE_HUMAN, APECED, APECED protein, APS1, APSI, Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein, Autoimmune regulator, Autoimmune regulator protein, PGA1, AIRE-1
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetAIRE
Short nameAIRE Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameautoimmune regulator (Antibody to)
Alternative techniqueantibodies
Alternative to gene target AIRE and IDBG-5152 and ENSG00000160224 and 326, AIRE and IDBG-639674 and ENSBTAG00000023393 and, AIRE1 and APECED and APS1 and APSI and PGA1, Aire and IDBG-168233 and ENSMUSG00000000731 and 11634, DNA-templated and biological process this GO :0006355 and regulation of transcription, DNA-templated and biological process this GO :0006417 and regulation of translation and biological process this GO :0006955 and immune response and biological process this GO :0006959 and humoral immune response and biological process this GO :0008270 and zinc ion binding and molecular function this GO :0042393 and histone binding and molecular function this GO :0042802 and identical protein binding and molecular function this GO :0044212 and transcription regulatory region DNA binding and molecular function this GO :0045087 and innate immune response and biological process this GO :0045182 and translation regulator activity and molecular function this GO :0045893 and positive regulation of transcription, DNA-templated and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process, nuclei, this GO :0003677 and DNA binding and molecular function this GO :0003682 and chromatin binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005622 and intracellular and cellular component this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0006351 and transcription, this GO :0003677: DNA binding, this GO :0003677: DNA binding and also this GO :0003682: chromatin binding and also this GO :0005515: protein binding and also this GO :0008270: zinc ion binding and also this GO :0042393: histone binding and also this GO :0042802: identical protein binding and also this GO :0044212: transcription regulatory region DNA binding and also this GO :0045182: translation regulator activity, this GO :0003682: chromatin binding, this GO :0005515: protein binding, this GO :0008270: zinc ion binding, this GO :0042393: histone binding, this GO :0042802: identical protein binding, this GO :0044212: transcription regulatory region DNA binding, this GO :0045182: translation regulator activity, translation regulator activity, autoimmune regulator
Identity 360
Gene AIRE
Long gene name autoimmune regulator
Synonyms gene APECED
Synonyms gene name autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)
Synonyms PGA1 APS1
Synonyms name autoimmune polyendocrinopathy candidiasis ectodermal dystrophy
Locus 21q22, 3
Discovery year 1997-09-05
GenBank acession AB006684
Entrez gene record 326
Pubmed identfication 9398840
Classification PHD finger proteins
Havana BLAST/BLAT OTTHUMG00000086921
Locus Specific Databases AIREbase: Mutation registry for APECED LRG_18

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