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AMPK alpha 1 (Ser496) Antibody, ALEXA FLUOR 647

AMPK alpha 1 (Ser496) Antibody, ALEXA FLUOR 647 size: 100ul 350

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES
Price 350
Size 100ul
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name ALEXA FLUOR 647 Conjugated, AMPK alpha 1 (Ser496) Antibody
Also known asAnti-AMPK alpha 1 Ser496 PAb ALEXA FLUOR 647
CategoryConjugated Primary Antibodies
Conjugated with 647, ALEXA FLUOR®
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenAMPK alpha 1 Ser496
SpecificityThis is a highly specific antibody against AMPK alpha 1 Ser496
ModificationPhosphorylation
Modification SiteSer496
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
SourceKLH conjugated synthetic phosphopeptide derived from mouse AMPK alpha 1 around the phosphorylation site of Ser496
Gene ID Number105787
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
Crossreactivity Mouse, Rat, Human
Cross-reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the antigen ACACB, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, AMPK acts via direct phosphorylation of metabolic enzymes, AMPK stimulates glucose uptake in muscle by increasing the translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane, Acts as a key regulator of cell growth and proliferation by phosphorylating TSC2, Acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton, EP300, FOXO3, GYS1, HDAC5, HMGCR and LIPE, HNF4A, In response to reduction of intracellular ATP levels, In response to stress, MEF2C, MLXIPL/ChREBP, PFKFB2 and PFKFB3, RPTOR and ATG1/ULK1: in response to nutrient limitation, Regulates insulin-signaling and glycolysis by phosphorylating IRS1, Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, Regulates transcription and chromatin structure by phosphorylating transcription regulators involved in energy metabolism such as CRTC2/TORC2, SREBF1, SREBF2 and PPARGC1A, an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism, and by longer-term effects via phosphorylation of transcription regulators, as well as cell growth and proliferation, carbohydrate and lipid biosynthesis, histone H2B, leading to CRTC2/TORC2 sequestration in the cytoplasm, leading to promote transcription, negatively regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and activating TSC2, p53/TP53, phosphorylates 'Ser-36' of histone H2B (H2BS36ph), possibly by mediating phosphorylation of TBC1D4/AS160, probably by indirectly activating myosin, regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively, Catalytic subunit of AMP-activated protein kinase (AMPK)
PurificationPurified by Protein A
Storage conditions 50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA
Excitation emission650nm/665nm
Synonyms AMPK AMPKa2
Properties ALEXA FLUOR made this Alexa Fluor 633 conjugate that can be used in multi-color flow cytometry with instruments equipped with a second red laser or red diode, ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 633 is a practical alternative to APC as well as Cy5, Bioss Primary Conjugated Antibodies, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is detected in the FL4 detector of the core's upgraded 2-laser FACScans, Like other Alexa Fluor dyes, exhibits uncommon photo stability, making it an ideal choice for fluorescent microscopy, the AMPK alpha 1 (Ser496) Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate
Conjugation ALEXA FLUOR 647, Alexa Fluor
Gene targetAMPK alpha 1 (Ser496)
Short nameAMPK alpha 1 (Ser496) Antibody
Technique antibodies against human proteins, antibodies for, Antibody
LabelALEXA FLUOR 647
Alternative name ALEXA FLUOR 647, AMPK a 1 (Ser496) (Antibody to)
Alternative techniqueantibodies
Identity 9377
Gene PRKAA2
Long gene name protein kinase AMP-activated catalytic subunit alpha 2
Synonyms gene PRKAA
Synonyms gene name AMP-activated, alpha 2 catalytic subunit , protein kinase
Locus 1p32, 2
Discovery year 1995-12-12
GenBank acession BC069823
Entrez gene record 5563
Pubmed identfication 7959015
RefSeq identity NM_006252
Havana BLAST/BLAT OTTHUMG00000008282

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