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Anti-GIT2 (Polyclonal), ALEXA Fluor 594

Anti-GIT2 (Polyclonal), ALEXA Fluor 594 size: 100 microliters 489

Supplier BIOSS POLYCLONAL ANTIBODIES
Price 489
Size 100 microliters
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
TypeConjugated Primary Antibody
Conjugated with 594, ALEXA FLUOR®
Host organismRabbit (Oryctolagus cuniculus)
Target Protein/PeptideGIT2
SpecificityThis antibody reacts specifically with GIT2
ModificationNo modification has been applied to this antibody
Modification siteNone
ClonalityPolyclonal Antibody
ClonePolyclonal Antibodies
Concentration1ug per 1ul
Subcellular locationsN/A
Antigen SourceKLH conjugated synthetic peptide derived from human GIT2
Gene ID9815
Swiss ProtN/A
ApplicationsIF(IHC-P)
Applications with corresponding dilutionsIF(IHC-P)(1:50-200)
Cross reactive species Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens)
Cross Reactive Species details However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species
Background information G protein-coupled receptor kinases (GRKs) are activated by activated G protein-coupled receptors, GIT1 (for GRK-interactor 1) and GIT2 are GTPase-activating proteins (GAP) for members of the ADP ribosylation factor (ARF) family of small GTP-binding proteins, GIT1 overexpression results in reduced internalization and resensitization of b2-adrenergic receptor, and they function to phosphorylate and inactivate cell surface receptors in the heterotrimeric G protein signaling cascade (3, thus reducing b2-adrenergic receptor signaling (5), which are involved in vesicular trafficking (5, 2), 4), 6), Heterotrimeric G protein-mediated signal transduction is a dynamically regulated process with the intensity of signal decreasing over time despite the continued presence of the agonist (1
Purification methodPurified by Protein A
Storage 50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA
Excitation emission590nm/617nm
Synonyms KIAA0148 PKL
Also known asGIT2 Polyclonal Antibody
Other nameAnti-GIT2 Polyclonal
Advisory For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody
PropertiesFor facs or microscopy Alexa 1 conjugate
ConjugationAlexa Fluor
GroupPolyclonals and antibodies
About The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot
Gene targetGIT2
Short nameAnti-GIT2 (Polyclonal) Fluor 594
Technique Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different 
LabelALEXA
Alternative name ALEXA Fluor 594, antibody to-GIT2 (polyclonal)
Alternative techniquepolyclonals
Identity 4273
Gene GIT2
Long gene name GIT ArfGAP 2
Synonyms gene name G protein-coupled receptor kinase interactor 2 G protein-coupled receptor kinase interacting ArfGAP 2
Synonyms name Paxillin kinase linker
Locus 12q24, 11
Discovery year 2000-07-31
GenBank acession AF124491
Entrez gene record 9815
Pubmed identfication 9826657 10896954
RefSeq identity NM_057169
Classification Ankyrin repeat domain containing ArfGAPs
Havana BLAST/BLAT OTTHUMG00000169313

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