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Anti-HUMAN Chk2 (pThr68)

Anti-HUMAN Chk2 (pThr68) size: 50ug 569

Supplier MBS POLYCLONALS 1
Price 569
Size 50ug
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Alternative name1Anti-RABBIT ANTI HUMAN Chk2 (pThr68)
Alternative name2RABBIT ANTI HUMAN Chk2 (pThr68)
Alternative name3Lapin ANTI Homo sapiens Chk2 (pThr68)
Alternative name4Chk2
Alternative name5N/A
Other names CHK2 checkpoint homolog, CHK2 checkpoint homolog, Cds1 homolog, Checkpoint kinase 2, Hucds1, Serine/threonine-protein kinase Chk2, cds1 homolog, checkpoint kinase 2, checkpoint-like protein CHK2, hCds1, serine/threonine-protein kinase Chk2, serine/threonine-protein kinase Chk2 isoform c
Gene nameChk2
Gene name synonimsN/A
Other gene names CDS1, CDS1, CHEK2, CHK2, CHK2, HuCds1, Hucds1, LFS2, PP1425, RAD53, RAD53, hCds1, hCds1, CHEK2
CategoryAntibodies
ClonalityPolyclonal
Immunoglobulin isotypePolyclonal IgG
ClonePolyclonal antibody
Host organismRabbit
Species reactivityHuman
Specificity and cross-reactivity ATM and ATR kinases are activated in response to ionizing and ultraviolet radiation, Chk2 can phosphorylate BRCA1, Chk2 is a serine/threonine-protein kinase which functions as a cell cycle checkpoint regulator, In addition, _x000D__x000D_Activated Chk2 phosphorylates and inhibits Cdc25C phosphatase, _x000D__x000D_Chk2 is a putative tumour suppressor protein, a familial cancer usually associated with inherited mutations in TP53, allowing BRCA1 to restore survival after DNA damage, and has been shown to stabilize the tumour suppressor protein p53, and phsophorylate Thr68 and other sites in the amino-terminal region of Chk2, leading to Chk2 dimerisation and activation, leading to cell cycle arrest in G1, phosphorylated at threonine 68 (Thr68), preventing the entry into mitosis, with mutations in to the Chk2 gene linked to Li-Fraumeni syndrome, Chk2 This item detects human Checkpoint kinase 2 (Chk2)
Purification methodN/A
Form/AppearancePurified (Purified IgG - liquid)
Concentration0mg/ml, IgG concentration 1
Storage and shipping Avoid repeated freezing and thawing as this may denature the antibody, Shelf Life: 18 months from date of dispatch, Should productone contain a precipitate we recommend microcentrifugation before use, Storage in frost-free freezers is not recommended, if preferred, or productone should be stored at -20 degrees Celsius, productone should be stored undiluted, Store at +Store productone at +4 degrees Celsius
Tested for: ELISA (EIA), Western Blot (WB)
Description Polyclonal antibodies generally are more stable and retain their reactivity under unfavorable conditions, Polyclonal antibodies have series of advantages - larger batches can be supplied at a time, Properly used, To obtain more detailed information on productone, please, refer to the full product datasheet, the time needed for production is considerably shorter, they are inexpensive to manufacture and respectively to buy, this antibody will ensure excellent and reproducible results with guaranteed success for the applications that it is tested in, productone is a polyclonal antibody of high purity and binding affinity for the antigen that it is risen against
Advisory For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, avoid cycles of freezing and thawing, please, In order to retain the quality and the affinity of productone unchanged
Gene targetChk2 (pThr68)
Short nameAnti-HUMAN Chk2 (pThr68)
Alternative name sapiens Chk2 (pThr68), antibody to-H

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