| Alternative name1 | Anti-RABBIT ANTI HUMAN E2F1 |
| Alternative name2 | RABBIT ANTI HUMAN E2F1 |
| Alternative name3 | Lapin ANTI Homo sapiens E2F1 |
| Alternative name4 | E2F1 |
| Alternative name5 | N/A |
| Other names | E2F transcription factor 1, PBR3, PBR3, PRB-binding protein E2F-1, RBAP-1, RBAP-1, RBBP-3, RBBP-3, Retinoblastoma-associated protein 1, Retinoblastoma-binding protein 3, Transcription factor E2F1, pRB-binding protein E2F-1, retinoblastoma-associated protein 1, retinoblastoma-binding protein 3, transcription factor E2F1, transcription factor E2F1 |
| Gene name | E2F1 |
| Gene name synonims | N/A |
| Other gene names | E2F-1, E2F-1, E2F1, RBAP-1, RBAP1, RBBP-3, RBBP3, RBBP3, RBP3, E2F1 |
| Category | Antibodies |
| Clonality | Polyclonal |
| Immunoglobulin isotype | Polyclonal IgG |
| Clone | Polyclonal antibody |
| Host organism | Rabbit |
| Species reactivity | Human |
| Specificity and cross-reactivity | E2F1 also binds to the retinoblastoma protein (RB1), E2F1 is a transcription activator that binds DNA cooperatively with the differentiation regulated transcription factor proteins (DP), It is a target of the transforming proteins of small DNA tumour viruses and increased expression of this protein has been reported in a variety of cancers, Together they bind to the promoter region of a number of genes whose products are involved in cell cycle regulation or DNA replication, _x000D__x000D_E2F1 can mediate p53-dependent and independent apoptosis, which functions in the control of cell-cycle progression from G1 to S phase, 9 kDa nuclear transcription protein, E2F1 This item recognises human E2F1 a 46, _x000D_ |
| Purification method | N/A |
| Form/Appearance | Purified (Purified IgG - liquid) |
| Concentration | 8 mg/ml, IgG concentration 0 |
| Storage and shipping | Avoid repeated freezing and thawing as this may denature the antibody, Shelf Life: 18 months from date of dispatch, Should productone contain a precipitate we recommend microcentrifugation before use, Storage in frost-free freezers is not recommended, if preferred, or productone should be stored at -20 degrees Celsius, productone should be stored undiluted, Store at +Store productone at +4 degrees Celsius |
| Tested for: | ELISA (EIA), Western Blot (WB), Immunohistology - Paraffin (IHC) |
| Description | Polyclonal antibodies generally are more stable and retain their reactivity under unfavorable conditions, Polyclonal antibodies have series of advantages - larger batches can be supplied at a time, Properly used, To obtain more detailed information on productone, please, refer to the full product datasheet, the time needed for production is considerably shorter, they are inexpensive to manufacture and respectively to buy, this antibody will ensure excellent and reproducible results with guaranteed success for the applications that it is tested in, productone is a polyclonal antibody of high purity and binding affinity for the antigen that it is risen against |
| Advisory | For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, avoid cycles of freezing and thawing, please, In order to retain the quality and the affinity of productone unchanged |
| Gene target | E2F1 |
| Short name | Anti-HUMAN E2F1 |
| Alternative name | sapiens E2F transcription factor 1, antibody to-H |
| Alternative to gene target | BT, DNA-templated and biological process this GO :0006355 and regulation of transcription, DNA-templated and biological process this GO :0006915 and apoptotic process and biological process this GO :0007219 and Notch signaling pathway and biological process this GO :0007283 and spermatogenesis and biological process this GO :0008134 and transcription factor binding and molecular function this GO :0008283 and cell proliferation and biological process this GO :0008630 and intrinsic apoptotic signaling pathway in response to DNA damage and biological process this GO :0010628 and positive regulation of gene expression and biological process this GO :0030900 and forebrain development and biological process this GO :0035189 and Rb-E2F complex and cellular component this GO :0043276 and anoikis and biological process this GO :0043565 and sequence-specific DNA binding and molecular function this GO :0045087 and innate immune response and biological process this GO :0045892 and negative regulation of transcription, DNA-templated and biological process this GO :0045893 and positive regulation of transcription, DNA-templated and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0048146 and positive regulation of fibroblast proliferation and biological process this GO :0048255 and mRNA stabilization and biological process this GO :0051726 and regulation of cell cycle and biological process this GO :0071398 and cellular response to fatty acid and biological process this GO :0071456 and cellular response to hypoxia and biological process this GO :0071930 and negative regulation of transcription involved in G1/S transition of mitotic cell cycle and biological process this GO :0072332 and intrinsic apoptotic signaling pathway by p53 class mediator and biological process this GO :0097193 and intrinsic apoptotic signaling pathway and biological process this GO :1900740 and positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway and biological process this GO :1990086 and lens fiber cell apoptotic process and biological process this GO :2000045 and regulation of G1/S transition of mitotic cell cycle and biological process, E2F-1 and RBAP1 and RBBP3 and RBP3, E2F1 and IDBG-67214 and ENSG00000101412 and 1869, E2f1 and IDBG-210416 and ENSMUSG00000027490 and 13555, nuclei, sequence-specific DNA binding, this GO :0000077 and DNA damage checkpoint and biological process this GO :0000080 and mitotic G1 phase and biological process this GO :0000082 and G1/S transition of mitotic cell cycle and biological process this GO :0000085 and mitotic G2 phase and biological process this GO :0000122 and negative regulation of transcription from RNA polymerase II promoter and biological process this GO :0000278 and mitotic cell cycle and biological process this GO :0001047 and core promoter binding and molecular function this GO :0003677 and DNA binding and molecular function this GO :0003700 and sequence-specific DNA binding transcription factor activity and molecular function this GO :0003714 and transcription corepressor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005667 and transcription factor complex and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0006351 and transcription, this GO :0001047: core promoter binding, this GO :0001047: core promoter binding and also this GO :0003677: DNA binding and also this GO :0003700: sequence-specific DNA binding transcription factor activity and also this GO :0003714: transcription corepressor activity and also this GO :0005515: protein binding and also this GO :0008134: transcription factor binding and also this GO :0043565: sequence-specific DNA binding, this GO :0003677: DNA binding, this GO :0003700: sequence-specific DNA binding transcription factor activity, this GO :0003714: transcription corepressor activity, this GO :0005515: protein binding, this GO :0008134: transcription factor binding, this GO :0043565: sequence-specific DNA binding, 78028 and IDBG-641855 and ENSBTAG00000003971 and 535369, E2F transcription factor 1 |
| Identity | 3113 |
| Gene | E2F1 |
| Long gene name | E2F transcription factor 1 |
| Synonyms gene | RBBP3 |
| Synonyms | RBP3 |
| Locus | 20q11, 22 |
| Discovery year | 1993-06-29 |
| Entrez gene record | 1869 |
| Pubmed identfication | 8964493 |
| Classification | E2F transcription factors |
| Havana BLAST/BLAT | OTTHUMG00000032265 |
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