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Anti-HUMAN PARKIN (pSer101)

Anti-HUMAN PARKIN (pSer101) size: 100ul 647

Supplier MBS POLYCLONALS 1
Price 647
Size 100ul
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Alternative name1Anti-RABBIT ANTI HUMAN PARKIN (pSer101)
Alternative name2RABBIT ANTI HUMAN PARKIN (pSer101)
Alternative name3Lapin ANTI Homo sapiens PARKIN (pSer101)
Alternative name4PARKIN
Alternative name5N/A
Other names E3 ubiquitin protein ligase (parkin), E3 ubiquitin-protein ligase parkin, E3 ubiquitin-protein ligase parkin, Parkinson disease (autosomal recessive, Parkinson juvenile disease protein 2, juvenile) 2, parkin, parkinson juvenile disease protein 2, parkinson protein 2, E3 ubiquitin-protein ligase parkin isoform 1
Gene nameN/A
Gene name synonimsN/A
Other gene names AR-JP, LPRS2, PARK2, PDJ, PRKN, PRKN, Parkinson disease protein 2, PARK2
CategoryAntibodies
ClonalityPolyclonal
Immunoglobulin isotypePolyclonal IgG
ClonePolyclonal antibody
Host organismRabbit
Species reactivityHuman
Specificity and cross-reactivity Mutations in the parkin gene are associated with the hereditary neurodegenerative disorder known as autosomal recessive early onset Parkinson disease 2 (PARK2)/autosomal recessive juvenile Parkinson disease (PDJ), Studies have identified the presence of at least five phosphorylation sites in parkin including Ser101, _x000D__x000D_Parkin is an E3 ubiquitin ligase highly expressed in the brain, and suggest that phosphorylation of parkin may act to regulate its ubiquitin ligase activity, characterized by progressive dopaminergic neural cell death, shown to be phosphorylated by Casein kinase-1 (CK-1), together with the E2 ubiquitin conjugating co-enzyme UbcH7, when phosphorylated at Ser101, which functions in the ubiquitin-proteasome system, PARKIN This item specifically recognises the 52kDa parkin protein
Purification methodN/A
Form/AppearancePurified (Purified IgG - liquid)
ConcentrationN/A
Storage and shipping Avoid repeated freezing and thawing as this may denature the antibody, Shelf Life: 12 months from date of dispatch, Should productone contain a precipitate we recommend microcentrifugation before use, Storage in frost-free freezers is not recommended, if preferred, or productone should be stored at -20 degrees Celsius, productone should be stored undiluted, Store at +Store productone at +4 degrees Celsius
Tested for:Western Blot (WB)
Description Polyclonal antibodies generally are more stable and retain their reactivity under unfavorable conditions, Polyclonal antibodies have series of advantages - larger batches can be supplied at a time, Properly used, To obtain more detailed information on productone, please, refer to the full product datasheet, the time needed for production is considerably shorter, they are inexpensive to manufacture and respectively to buy, this antibody will ensure excellent and reproducible results with guaranteed success for the applications that it is tested in, productone is a polyclonal antibody of high purity and binding affinity for the antigen that it is risen against
Advisory For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, avoid cycles of freezing and thawing, please, In order to retain the quality and the affinity of productone unchanged
Gene targetPARKIN (pSer101)
Short nameAnti-HUMAN PARKIN (pSer101)
Alternative name sapiens PARKIN (pSer101), antibody to-H
Identity 8607
Gene PARK2
Long gene name parkin RBR E3 ubiquitin protein ligase
Synonyms gene name E3 ubiquitin protein ligase (parkin) , Parkinson disease (autosomal recessive, juvenile) 2, parkin parkinson protein 2
Synonyms PDJ AR-JP parkin PRKN
Synonyms name E3 ubiquitin ligase
Locus 6q26
Discovery year 1997-08-18
Entrez gene record 5071
Pubmed identfication 9560156 9570960
Classification Parkinson disease associated genes RBR E3 ubiquitin ligases
Havana BLAST/BLAT OTTHUMG00000015970
Locus Specific Databases Parkinson', s disease Mutation Database

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