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Anti-MELK/HPK38 (Polyclonal), ALEXA Fluor 594

Anti-MELK/HPK38 (Polyclonal), ALEXA Fluor 594 size: 100 microliters 489

Supplier BIOSS POLYCLONAL ANTIBODIES
Price 489
Size 100 microliters
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
TypeConjugated Primary Antibody
Conjugated with 594, ALEXA FLUOR®
Host organismRabbit (Oryctolagus cuniculus)
Target Protein/PeptideMELK/HPK38
SpecificityThis antibody reacts specifically with MELK/HPK38
ModificationNo modification has been applied to this antibody
Modification siteNone
ClonalityPolyclonal Antibody
ClonePolyclonal Antibodies
Concentration1ug per 1ul
Subcellular locationsCell membrane
Antigen SourceKLH conjugated synthetic peptide derived from human MELK/HPK38
Gene ID9833
Swiss ProtQ14680
ApplicationsIF(IHC-P)
Applications with corresponding dilutionsIF(IHC-P)(1:50-200)
Cross reactive species Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens)
Cross Reactive Species details However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species
Background information Acts as a regulator of cell cycle, Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1, Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, CDC25B, Has a broad substrate specificity, MAP3K5/ASK1 and ZNF622, May also play a role in primitive hematopoiesis, Phosphorylates and inhibits BCL2L14, Plays a key role in cell proliferation and carcinogenesis, Required for proliferation of embryonic and postnatal multipotent neural progenitors, apoptosis and splicing regulation, notably by mediating phosphorylation of CDC25B, phosphorylates BCL2L14, possibly leading to affect mammary carcinogenesis by mediating inhibition of the pro-apoptotic function of BCL2L14, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis, self-renewal of stem cells, thereby contributing to its redirection to the nucleus, Serine/threonine-protein kinase involved in various processes such as cell cycle regulation
Purification methodPurified by Protein A
Storage 50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA
Excitation emission590nm/617nm
Synonyms KIAA0175
Also known asMELK/HPK38 Polyclonal Antibody
Other nameAnti-MELK/HPK38 Polyclonal
Advisory For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody
PropertiesFor facs or microscopy Alexa 1 conjugate
ConjugationAlexa Fluor
GroupPolyclonals and antibodies
About The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot
Gene targetMELK/HPK38
Short nameAnti-MELK/HPK38 (Polyclonal) Fluor 594
Technique Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different 
LabelALEXA
Alternative name ALEXA Fluor 594, antibody to-MELK/HPK38 (polyclonal)
Alternative techniquepolyclonals
Identity 16870
Gene MELK
Long gene name maternal embryonic leucine zipper kinase
Locus 9p13, 2
Discovery year 2003-02-04
GenBank acession D79997
Entrez gene record 9833
Pubmed identfication 8724849 9136115
RefSeq identity NM_014791
Havana BLAST/BLAT OTTHUMG00000019906

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