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Anti-Mre11 (Polyclonal), ALEXA Fluor 594

Anti-Mre11 (Polyclonal), ALEXA Fluor 594 size: 100 microliters 489

Supplier BIOSS POLYCLONAL ANTIBODIES
Price 489
Size 100 microliters
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
TypeConjugated Primary Antibody
Conjugated with 594, ALEXA FLUOR®
Host organismRabbit (Oryctolagus cuniculus)
Target Protein/PeptideMre11
SpecificityThis antibody reacts specifically with Mre11
ModificationNo modification has been applied to this antibody
Modification siteNone
ClonalityPolyclonal Antibody
ClonePolyclonal Antibodies
Concentration1ug per 1ul
Subcellular locationsNucleus
Antigen SourceKLH conjugated synthetic peptide derived from human Mre11/HNGS1
Gene ID4361
Swiss ProtP49959
ApplicationsIF(IHC-P)
Applications with corresponding dilutionsIF(IHC-P)(1:50-200)
Cross reactive species Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens)
Cross Reactive Species details However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species
Background information DNA recombination, In telomeres the MRN complex may modulate t-loop formation, RAD50 may be required to bind DNA ends and hold them in close proximity, The complex may also be required for DNA damage signaling via activation of the ATM kinase, The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point, maintenance of telomere integrity and meiosis, which are provided by MRE11A, which plays a central role in double-strand break (DSB) repair, Component of the MRN complex
Purification methodPurified by Protein A
Storage 50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA
Excitation emission590nm/617nm
Synonyms ATLD
Also known asMre11 Polyclonal Antibody
Other nameAnti-Mre11 Polyclonal
Advisory For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody
PropertiesFor facs or microscopy Alexa 1 conjugate
ConjugationAlexa Fluor
GroupPolyclonals and antibodies
About The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot
Gene targetMre11
Short nameAnti-Mre11 (Polyclonal) Fluor 594
Technique Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different 
LabelALEXA
Alternative name ALEXA Fluor 594, antibody to-Mre11 (polyclonal)
Alternative techniquepolyclonals
Identity 7230
Gene MRE11
Long gene name MRE11 homolog, double strand break repair nuclease
Synonyms gene MRE11A
Synonyms gene name MRE11 meiotic recombination 11 homolog A (S, cerevisiae) MRE11 homolog A, double strand break repair nuclease
Synonyms name AT-like disease
Locus 11q21
Discovery year 1995-05-05
GenBank acession BC063458
Entrez gene record 4361
Pubmed identfication 8530104 24316220
RefSeq identity NM_005591
Classification BRCA1 C complex MRN complex
Havana BLAST/BLAT OTTHUMG00000167780
Locus Specific Databases MRE11Abase: Mutation registry for Ataxia-telangiectasia-like disorder (ATLD) LRG_85

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