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Anti-MYPT1 (Ser507) (Polyclonal), ALEXA Fluor 594

Anti-MYPT1 (Ser507) (Polyclonal), ALEXA Fluor 594 size: 100 microliters 516

Supplier BIOSS POLYCLONAL ANTIBODIES
Price 516
Size 100 microliters
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
TypeConjugated Primary Antibody
Conjugated with 594, ALEXA FLUOR®
Host organismRabbit (Oryctolagus cuniculus)
Target Protein/PeptideMYPT1 Ser507
SpecificityThis antibody reacts specifically with MYPT1 (Ser507)
ModificationPhosphorylation
Modification siteSer507
ClonalityPolyclonal Antibody
ClonePolyclonal Antibodies
Concentration1ug per 1ul
Subcellular locationsN/A
Antigen SourceKLH conjugated synthetic phosphopeptide derived from human MYPT1 around the phosphorylation site of Ser507
Gene ID4659
Swiss ProtN/A
ApplicationsIF(IHC-P)
Applications with corresponding dilutionsIF(IHC-P)(1:50-200)
Cross reactive species Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens)
Cross Reactive Species details However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species
Background information Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho, Overexpression of RhoA or activated RhoA in NIH 3T3 cells increased phosphorylation of MBS and MLC, Rho appears to inhibit myosin phosphatase through the action of Rho-kinase, Rho-associated kinase (Rho-kinase), RhoA, Several transcript variants encoding different isoforms have been found for this gene, The guanosine triphosphate(GTP)-bound, The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, Thus, [provided by RefSeq], active form of RhoA (GTP, is one of the subunits of myosin phosphatase, phosphorylated MBS and consequently inactivated myosin phosphatase, which is activated by GTP, which is also called the myosin-binding subunit of myosin phosphatase, which regulates the extent of phosphorylation of MLC, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells, Myosin phosphatase target subunit 1, RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase
Purification methodPurified by Protein A
Storage 50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA
Excitation emission590nm/617nm
Synonyms MBS M130
Also known asMYPT1 (Ser507) Polyclonal Antibody
Other nameAnti-MYPT1 (Ser507) Polyclonal
Advisory For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody
PropertiesFor facs or microscopy Alexa 1 conjugate
ConjugationAlexa Fluor
GroupPolyclonals and antibodies
About The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot
Gene targetMYPT1 (Ser507)
Short nameAnti-MYPT1 (Ser507) (Polyclonal) Fluor 594
Technique Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different 
LabelALEXA
Alternative name ALEXA Fluor 594, antibody to-MYPT1 (Ser507) (polyclonal)
Alternative techniquepolyclonals
Identity 7618
Gene PPP1R12A
Long gene name protein phosphatase 1 regulatory subunit 12A
Synonyms gene MYPT1
Synonyms gene name protein phosphatase 1, regulatory (inhibitor) subunit 12A protein phosphatase 1, regulatory subunit 12A
Synonyms name myosin phosphatase-targeting subunit 1 myosin binding subunit
Locus 12q21, 2-q21, 31
Discovery year 1997-12-23
GenBank acession D87930
Entrez gene record 4659
Pubmed identfication 9286714
RefSeq identity NM_002480
Classification Ankyrin repeat domain containing Protein phosphatase 1 regulatory subunits
Havana BLAST/BLAT OTTHUMG00000170100

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