Anti-TLE4 (Polyclonal), ALEXA Fluor 594

Anti-TLE4 (Polyclonal), ALEXA Fluor 594 size: 100 microliters 489

Price 489

Size 100 microliters

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Type	Conjugated Primary Antibody
Conjugated with	594, ALEXA FLUOR®
Host organism	Rabbit (Oryctolagus cuniculus)
Target Protein/Peptide	TLE4
Specificity	This antibody reacts specifically with TLE4
Modification	No modification has been applied to this antibody
Modification site	None
Clonality	Polyclonal Antibody
Clone	Polyclonal Antibodies
Concentration	1ug per 1ul
Subcellular locations	N/A
Antigen Source	KLH conjugated synthetic peptide derived from human TLE4
Gene ID	7091
Swiss Prot	N/A
Applications	IF(IHC-P)
Applications with corresponding dilutions	IF(IHC-P)(1:50-200)
Cross reactive species	Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens)
Cross Reactive Species details	However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species
Background information	Expression of the TLE genes, Groucho is a transcriptional repressor that plays a key role in neurogenesis, In early stages of cell differentiation, In later stages, Key players in the Notch pathway are the TLE genes (for transducin-like enhancer of split, TLE1, TLE1, TLE1 and TLE4 contain SP and WD40 domains, TLE1 is upregulated, TLE2, TLE2 and TLE3 have elevated expression in cervical squamous metaplasias and carcinomas, TLE2 and TLE4 are upregulated, TLE3 and TLE4, TLEs associate with chromatin in live cells and specifically with Histone H3, also designated ESG for enhancer of split groucho), and TLE2 and TLE4 are downregulated, and expression of TLE1 decreases, but not with other core histones, correlate with immature epithelial cells that are progressing toward a terminally differentiated state, particularly in the caudate nucleus, segmentation and sex determination, suggesting a role during epithelial differentiation, through which TLE1 binds AML1 to inhibit AML1-induced transactivation of the CSF1 receptor, which are human homologs of the Drosophila groucho gene, while TLE4 is most highly expressed in the brain, The Notch signaling pathway controls cellular interactions important for the specification of a variety of fates in both invertebrates and vertebrates
Purification method	Purified by Protein A
Storage	50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA
Excitation emission	590nm/617nm
Synonyms	E(spI) ESG GRG4
Also known as	TLE4 Polyclonal Antibody
Other name	Anti-TLE4 Polyclonal
Advisory	For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody
Properties	For facs or microscopy Alexa 1 conjugate
Conjugation	Alexa Fluor
Group	Polyclonals and antibodies
About	The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot
Gene target	TLE4
Short name	Anti-TLE4 (Polyclonal) Fluor 594
Technique	Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different
Label	ALEXA
Alternative name	ALEXA Fluor 594, antibody to-TLE4 (polyclonal)
Alternative technique	polyclonals
Identity	11840
Gene	TLE4
Long gene name	transducin like enhancer of split 4
Synonyms gene name	Drosophila) , transducin-like enhancer of split 4 (E(sp1) homolog
Locus	9q21, 31
Discovery year	1993-12-20
GenBank acession	M99439
Entrez gene record	7091
Pubmed identfication	8365415
RefSeq identity	XM_212237
Classification	WD repeat domain containing
Havana BLAST/BLAT	OTTHUMG00000020072

Anti-TLE4 (Polyclonal), ALEXA Fluor 594

Anti-TLE4 (Polyclonal), ALEXA Fluor 594 size: 100 microliters 489

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