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Anti-TrkA (Tyr680 + Tyr681)/TrkB (Tyr706 + Tyr707), ALEXA Fluor 594

Anti-TrkA (Tyr680 + Tyr681)/TrkB (Tyr706 + Tyr707), ALEXA Fluor 594 size: 100 microliters 516

Supplier BIOSS POLYCLONAL ANTIBODIES
Price 516
Size 100 microliters
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
TypeConjugated Primary Antibody
Conjugated with 594, ALEXA FLUOR®
Host organismRabbit (Oryctolagus cuniculus)
Target Protein/Peptide TrkB Tyr706 + Tyr707, TrkA Tyr680 + Tyr681
Specificity These sites in TrkB are homologous to those of Tyr705 and Tyr706 in Mouse and Rat, The phosphorylation sites Tyr680 and Tyr681 in TrkA are homologous to those of Tyr683 and Tyr683 in Mouse and Rat, TrkA (Tyr680 + Tyr681)/TrkB (Tyr706 + Tyr707)
ModificationPhosphorylation
Modification siteTyr680+ Tyr681
ClonalityPolyclonal Antibody
ClonePolyclonal Antibodies
Concentration1ug per 1ul
Subcellular locationsCell membrane
Antigen SourceKLH conjugated synthetic phosphopeptide derived from human TrkB around the phosphorylation site of Tyr680/681
Gene ID4914
Swiss ProtP04629
ApplicationsIF(IHC-P)
Applications with corresponding dilutionsIF(IHC-P)(1:50-200)
Cross reactive species Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens)
Cross Reactive Species details However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species
Background information Antagonizes the anti-proliferative NGF-NTRK1 signaling that promotes neuronal precursors differentiation, FRS2, High affinity receptor for NGF which is its primary ligand, However, In absence of ligand and activation, Isoform TrkA-III is resistant to NGF, Isoform TrkA-III promotes angiogenesis and has oncogenic activity when overexpressed, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival, Recruits, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation, Through PLCG1 controls NF-Kappa-B activation and the transcription of genes involved in cell survival, Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival, Through SHC1 and SH2B1 controls a Ras-PI3 kinase-AKT1 signaling cascade that is also regulating survival, Upon dimeric NGF ligand-binding, autophosphorylation and activation, constitutively activates AKT1 and NF-kappa-B and is unable to activate the Ras-MAPK signaling cascade, differentiation and survival of sympathetic and nervous neurons, it can also bind and be activated by NTF3/neurotrophin-3, making the survival of neurons dependent on trophic factors, may promote cell death, phosphorylates and/or activates several downstream effectors including SHC1, undergoes homodimerization, Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation
Purification methodPurified by Protein A
Storage 50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA
Excitation emission590nm/617nm
Synonyms High affinity nerve growth factor receptor, NTRK1, Neurotrophic tyrosine kinase receptor type 1, TRK, TRK1, TRK1-transforming tyrosine kinase protein, TRKA, Trk-A, Tropomyosin-related kinase A, Tyrosine kinase receptor, Tyrosine kinase receptor A, gp140trk, p140-TrkA, MTC
Also known asTrkA (Tyr680 + Tyr681)/TrkB (Tyr706 + Tyr707) Antibody
Other nameAnti-TrkA (Tyr680 + Tyr681)/TrkB (Tyr706 + Tyr707)
Advisory For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody
PropertiesFor facs or microscopy Alexa 1 conjugate
ConjugationAlexa Fluor
Gene targetTrkA (Tyr680 + Tyr681)/TrkB (Tyr706 + Tyr707)
Short nameAnti-TrkA (Tyr680 + Tyr681)/TrkB (Tyr706 + Tyr707) Fluor 594
LabelALEXA
Alternative name ALEXA Fluor 594, antibody to-TrkA (Tyr680 and Tyr681)/TrkB (Tyr706 and Tyr707)

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