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anti-Tryptophan (phospho Ser58) Hydroxylase Antibody

anti-Tryptophan (phospho Ser58) Hydroxylase Antibody size: 0.1 mL 180

Supplier PROSCIENCE
Price 180
Size 0.1 mL
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Gene info Although TPH catalyzes the same reaction within the raphe nuclei and the pineal gland, Both PKA and CAM K II phosphorylate Ser58 which lies within the regulatory domain of TPH, In mammals, Serotonin functions mainly as a neurotransmitter, TPH activity is rate-limiting for serotonin but not melatonin biosynthesis, The activity of TPH is enhanced by phosphorylation by cAMP-dependent protein kinase (PKA) and Ca2+/calmodulin kinase II (CAM K II), and melatonin synthesis takes place within the pineal gland, serotonin biosynthesis occurs predominantly in neurons which originate in the raphe nuclei of the brain, whereas melatonin is the principal hormone secreted by the pineal gland, which is the first step in the biosynthesis of indoleamines (serotonin and melatonin), Tryptophan hydroxylase (TPH) catalyzes the 5-hydroxylation of tryptophan
Gene names Tph, Tryptophan 5-monooxygenase 1, Tph
Antibodie's labelunlabelled serum
PurityAffinity Purified
Ab raised inRabbit
TypePolyclonal
Spicific toTryptophan Hydroxylase antibody is specific immunolabeling of the ~55k TPH protein phosphorylated at Ser58 in Western blots of human dorsal Raphe nucleus
AntigenTPH (Ser58) polyclonal antibody was made against a synthetic phosphopeptide corresponding to amino acid residues surrounding the phosphoSer58 of TPH
Immuno applicationWestern Blot
Antibody advice When internally tested under ideal conditions the working dilutions were 1:1000 for DB and WB, Applications include Dot Blots (DB) and Western Blots (WB)
Suspention, pH, azide 100 ug per mL BSA and 50% glycerol, 150 mM NaCl, 100 uL in 10 mM HEPES (pH 7, 5)
Keep at Stable for one year, but shorter term storage at &ndash, 20 grades C is also acceptable as aliquots may be taken without freeze/thawing due to the presence of 50% glycerol, 80 grades C is recommended, For long term storage &ndash
Works with Mouse, Rat, Human
Omim nr136122
Ncbi nrP09810
KDa55
Vial with antibodyin solution
NCBI GENE nr24848
GENE symbolTph1
Antigene nametryptophan hydroxylase 1
SourceRattus norvegicus
Protein nrP09810
Description Freeze thaw will destroy a percentage in every cycle and should be avoided, C in a fridge short term in a concentrated dilution, This antibody needs to be stored at + 4°
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by proscience they should be stored frozen at - 24°
Gene targetTryptophan (phospho Ser58) Hydroxylase
Short nameanti-Tryptophan (phospho Ser58) Hydroxylase Antibody
Technique antibodies against human proteins, antibodies for, antibody to, Antibody
Alternative nameantibody to-Tryptophan (phosphorilated Ser58) Hydroxylase (Antibody to)
Alternative techniqueantibodies

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