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Anti-VHL/HRCA1 (Polyclonal), ALEXA Fluor 594

Anti-VHL/HRCA1 (Polyclonal), ALEXA Fluor 594 size: 100 microliters 489

Supplier BIOSS POLYCLONAL ANTIBODIES
Price 489
Size 100 microliters
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
TypeConjugated Primary Antibody
Conjugated with 594, ALEXA FLUOR®
Host organismRabbit (Oryctolagus cuniculus)
Target Protein/PeptideVHL/HRCA1
SpecificityThis antibody reacts specifically with VHL/HRCA1
ModificationNo modification has been applied to this antibody
Modification siteNone
ClonalityPolyclonal Antibody
ClonePolyclonal Antibodies
Concentration1ug per 1ul
Subcellular locationsN/A
Antigen SourceKLH conjugated synthetic peptide derived from human VHL
Gene ID7428
Swiss ProtN/A
ApplicationsIF(IHC-P)
Applications with corresponding dilutionsIF(IHC-P)(1:50-200)
Cross reactive species Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens)
Cross Reactive Species details However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species
Background information A germline mutation of this gene is the basis of familial inheritance of VHL syndrome, Alternatively spliced transcript variants encoding distinct isoforms have been observed, RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein, The protein encoded by this gene is a component of the protein complex that includes elongin B, This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), [provided by RefSeq], and cullin-2, and possesses ubiquitin ligase E3 activity, elongin C, which is a transcription factor that plays a central role in the regulation of gene expression by oxygen, Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors
Purification methodPurified by Protein A
Storage 50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA
Excitation emission590nm/617nm
Synonyms VHL1
Also known asVHL/HRCA1 Polyclonal Antibody
Other nameAnti-VHL/HRCA1 Polyclonal
Advisory For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody
PropertiesFor facs or microscopy Alexa 1 conjugate
ConjugationAlexa Fluor
GroupPolyclonals and antibodies
About The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot
Gene targetVHL/HRCA1
Short nameAnti-VHL/HRCA1 (Polyclonal) Fluor 594
Technique Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different 
LabelALEXA
Alternative name ALEXA Fluor 594, E3 ubiquitin protein ligase/HRCA1 (polyclonal), antibody to-von Hippel-Lindau tumor suppressor
Alternative techniquepolyclonals
Alternative to gene target BT, DNA-templated and biological process this GO :0006508 and proteolysis and biological process this GO :0006950 and response to stress and biological process this GO :0008134 and transcription factor binding and molecular function this GO :0008285 and negative regulation of cell proliferation and biological process this GO :0016020 and membrane and cellular component this GO :0016567 and protein ubiquitination and biological process this GO :0019899 and enzyme binding and molecular function this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0045111 and intermediate filament cytoskeleton and cellular component this GO :0045597 and positive regulation of cell differentiation and biological process this GO :0045893 and positive regulation of transcription, DNA-templated and biological process this GO :0050821 and protein stabilization and biological process this GO :0061418 and regulation of transcription from RNA polymerase II promoter in response to hypoxia and biological process this GO :0061428 and negative regulation of transcription from RNA polymerase II promoter in response to hypoxia and biological process this GO :0071456 and cellular response to hypoxia and biological process, E3 ubiquitin protein ligase, HRCA1 and pVHL and RCA1 and VHL1, VHL and IDBG-17819 and ENSG00000134086 and 7428, Vhl and IDBG-178105 and ENSMUSG00000033933 and 22346, enzyme binding, nuclei, this GO :0000122 and negative regulation of transcription from RNA polymerase II promoter and biological process this GO :0000902 and cell morphogenesis and biological process this GO :0004842 and ubiquitin-protein transferase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005739 and mitochondrion and cellular component this GO :0005783 and endoplasmic reticulum and cellular component this GO :0005829 and cytosol and cellular component this GO :0006355 and regulation of transcription, this GO :0004842: ubiquitin-protein transferase activity, this GO :0004842: ubiquitin-protein transferase activity and also this GO :0005515: protein binding and also this GO :0008134: transcription factor binding and also this GO :0019899: enzyme binding, this GO :0005515: protein binding, this GO :0008134: transcription factor binding, this GO :0019899: enzyme binding, 79817 and IDBG-644624 and ENSBTAG00000016101 and 540957, von Hippel-Lindau tumor suppressor
Identity 12687
Gene VHL
Long gene name von Hippel-Lindau tumor suppressor
Synonyms gene name E3 ubiquitin protein ligase , von Hippel-Lindau syndrome von Hippel-Lindau tumor suppressor
Locus 3p25, 3
Discovery year 1986-01-01
GenBank acession L15409
Entrez gene record 7428
Pubmed identfication 9671762
RefSeq identity NM_000551
Havana BLAST/BLAT OTTHUMG00000128668
Locus Specific Databases UMD Locus Specific Databases LRG_322

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