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Ataxin 3 Antibody / ATXN3

Ataxin 3 Antibody / ATXN3 size: 0.1mg 406

Supplier NJS POLY
Price 406
Size 0.1mg
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
CategoryAntibody
Concentration2ml sterile DI water, 5mg/ml if reconstituted with 0
FormAntigen affinity purified
ConjugationUnconjugated
ClonePolyclonal antibody
Recognised antigenAtaxin 3 / ATXN3
Host animalRabbit (Oryctolagus cuniculus)
ClonalityPolyclonal (rabbit origin)
Species reactivity Due to limited knowledge and inability to test the antibody against all known species, Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens)
Tested applications IHC-P, WB
Recommended dilutions1-0, 5-1ug/ml, 5ug/ml, IHC (Paraffin): 0, Western blot: 0
NotesOptimal dilution of the ATXN3 antibody should be determined by the researcher
Intented useThis ATXN3 antibodyis to be used only for research purposes and not for diagnostics
Uniprot #P54252
PurityAntigen affinity
Description 1, 4, ATX3, ATXN3 ranges in size from 360 to 374 amino acids, Alternatively spliced transcript variants encoding different isoforms have been described for this gene, Ataxin-3 interacted with 2 human homologs of the yeast DNA repair protein RAD23, Both normal and mutant ataxin-3 proteins interacted with the ubiquitin-like domain at the N terminus of the HHR23 proteins, HHR23A (RAD23A) and HHR23B (RAD23B), HHR23A was recruited to intranuclear inclusions formed by the mutant ataxin-3 through its interaction with ataxin-3, However, JOS, MJD GENE, MJD1, Machado-Joseph disease, Machado-Joseph disease protein 1, SCA3 GENE, Spinocerebellar ataxia-3, The protein encoded by the ATXN3 gene contains (CAG)n repeats in the coding region, There is an inverse correlation between the age of onset and CAG repeat numbers, They detected at least 4 ATXN3 transcripts of 1, Using Northern blot analysis showed that ATXN3 mRNA was ubiquitously expressed in human tissues, also known as AT3, also known as spinocerebellar ataxia-3, and 7, and the expansion of these repeats from the normal 13-36 to 68-79 is the cause of Machado-Joseph disease, in HEK 293 cells, is a protein that in humans is encoded by the ATXN3 gene, is an autosomal dominant neurologic disorder, which is a motif important for nucleotide excision repair, 4, 5, 5 kb and suggested that the different mRNA species probably result from differential splicing and polyadenylation, 8, ATXN3 (Ataxin 3)
ImmunogenAmino acids EEDLQRALALSRQEIDMEDEEADLRRAIQ of human Ataxin 3 were used as the immunogen for the ATXN3 antibody
Storage Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the ATXN3 antibody may be kept for up to one month refrigerated at +4 degrees C, After reconstitution, For long-term
LocalizationNuclear and cytoplasmic
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°
Gene targetAtaxin 3 / ATXN3
Short nameAtaxin 3 Antibody / ATXN3
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameAtaxin 3 (Antibody to) / ATXN3
Alternative techniqueantibodies
Identity 7106
Gene ATXN3
Long gene name ataxin 3
Synonyms gene SCA3 MJD
Synonyms gene name Machado-Joseph disease (spinocerebellar ataxia 3, ataxin 3) , autosomal dominant, olivopontocerebellar ataxia 3
Synonyms ATX3 JOS
Locus 14q32, 12
Discovery year 1987-09-11
GenBank acession U64820
Entrez gene record 4287
Pubmed identfication 8358439
RefSeq identity NM_004993
Classification Ataxins MJD deubiquinating enzymes
Havana BLAST/BLAT OTTHUMG00000162212
Locus Specific Databases LRG_865

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