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BACE2C Antibody

BACE2C Antibody size: 0.08 ml 199

Supplier NJS POLY
Price 199
Size 0.08 ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
CategoryAntibody
Concentration09% sodium azide, 4 with 0, In 1X PBS pH 7
FormPurified
ConjugationUnconjugated
ClonePolyclonal antibody
Recognised antigenBACE2C
Host animalRabbit (Oryctolagus cuniculus)
ClonalityPolyclonal (rabbit origin)
Species reactivity Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens)
Tested applications ELISA, IHC, WB
Recommended dilutionsIHC (Paraffin): 1:50-1:100, Western blot: 1:1000
NotesTitration of the BACE2C antibody may be required due to differences in protocols and secondary/substrate sensitivity
Intented useThis BACE2C antibodyis to be used only for research purposes and not for diagnostics
Uniprot #Q9Y5Z0
PurityPurified
Description Amyloid-beta is generated by proteolytic processing of the amyloid precursor protein (APP) by beta- and gamma-secretase at the N and C termini, BACE is a transmembrane aspartyl protease with beta-secretase activity, BACE2, BACE2 has been mapped to 21q22, In situ hybridization analysis of rat brain found low-level BACE2 expression in contrast to BACE expression, Low levels were also detected in brain, Northern blot analysis revealed low expression of 2, Presenilin-1 is involved in the gamma-secretase activity, The BACE2 expression pattern does not appear to be consistent with that of a beta-secretase, a propeptide, a signal sequence, also termed ALP56 has 2 pepsin-like active centers, and a long C-terminal extension including a transmembrane domain, and trachea, kidney, pancreas, placenta, prostate, respectively, stomach, with expression in a wide array of tissues, with higher expression in adult colon, with somewhat higher expression in medulla and spinal cord, within the Down syndrome critical region, 0- and 2, 3, 6-kb BACE2 transcripts in most fetal and adult tissues, Amyloid-beta peptide aggregation is a signature of Alzheimer disease and a frequent complication of adult Down syndrome patients
ImmunogenA portion of amino acids 310-339 from the human protein was used as the immunogen for this BACE2C antibody
Storage Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the BACE2C antibody and store frozen at -20 deg
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°
Gene targetBACE2C
Short nameBACE2C Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameBACE2C (Antibody to)
Alternative techniqueantibodies

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