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BAP1 Antibody

BAP1 Antibody size: 0.08 ml 199

Supplier NJS POLY
Price 199
Size 0.08 ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
CategoryAntibody
Concentration pH 7, with 0, 09% sodium azide, 4, In 1X PBS
FormPurified
ConjugationUnconjugated
ClonePolyclonal antibody
Recognised antigenBAP1
Host animalRabbit (Oryctolagus cuniculus)
ClonalityPolyclonal (rabbit origin)
Species reactivity Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus) , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens)
Tested applications ELISA, IHC, WB
Recommended dilutionsIHC (Paraffin): 1:50-1:100, Western blot: 1:1000
NotesTitration of the BAP1 antibody may be required due to differences in protocols and secondary/substrate sensitivity
Intented useThis BAP1 antibodyis to be used only for research purposes and not for diagnostics
Uniprot #Q92560
PurityPurified
Description BAP1 and BRCA1 associate in vivo and have overlapping subnuclear localization patterns, BAP1 contains an acidic region, In addition, It has been postulated that BAP1 is a tumor suppressor gene that functions in the BRCA1 growth control pathway, Northern blot analysis and in situ hybridization reveal that BAP1 and BRCA1 are coexpressed during murine breast development and remodeling, Northern blot analysis indicates that BAP1 is expressed as a 4-kb mRNA in all human tissues tested, The BAP1 gene has been mapped to 3p21, The N-terminal 240 amino acids of the predicted 729-amino acid human protein show homology to ubiquitin C-terminal hydrolases (UCHs), a highly charged C-terminal region, a region of loss of heterozygosity for breast cancer as well as frequently deleted in lung carcinomas, and 2 putative nuclear localization signals, thiol proteases that catalyze proteolytic processing of ubiquitin, with A 4, ' or BAP1 interacts with the RING finger domain of BRCA1, 'BRCA1-associated protein-1, 1, 1 BAP1 enhances BRCA1-mediated inhibition of breast cancer cell growth, 1 Intragenic homozygous rearrangements and deletions of BAP1 appear in lung carcinoma cell lines, 3, 8-kb transcript expressed exclusively in testis
ImmunogenA portion of amino acids 36-66 from the human protein was used as the immunogen for this BAP1 antibody
Storage Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the BAP1 antibody and store frozen at -20 deg
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°
Gene targetBAP1
Short nameBAP1 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameBAP1 (Antibody to)
Alternative techniqueantibodies
Identity 950
Gene BAP1
Long gene name BRCA1 associated protein 1
Synonyms gene name BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
Synonyms hucep-6 KIAA0272 UCHL2
Synonyms name ubiquitin carboxy-terminal hydrolase
Locus 3p21, 1
Discovery year 1998-09-17
GenBank acession AF045581
Entrez gene record 8314
Pubmed identfication 9528852
Classification Ubiquitin C-terminal hydrolases
Havana BLAST/BLAT OTTHUMG00000158392
Locus Specific Databases LRG_529

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