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BLNK Antibody

BLNK Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameBLNK Primary Polyclonal Antibody
Also known asBLNK PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenBLNK
SpecificityThis is a highly specific antibody against BLNK
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range330-380/456
Subcellular location Cell membrane, Cytoplasm
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human BLNK
Gene ID number29760
Swiss ProtQ8WV28
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen However, Important for the activation of NF-kappa-B and NFAT, MAP kinase p38 and JNK, May be required for the RAC1-JNK pathway, May play an important role in BCR-induced B-cell apoptosis, Modulates AP1 activation, Plays a critical role in orchestrating the pro-B cell to pre-B cell transition, Plays a role in the activation of ERK/EPHB2, Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes, bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling, downstream of the B-cell receptor (BCR), Functions as a central linker protein
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names AGM4, B-cell adapter containing a SH2 domain protein, B-cell adapter containing a Src homology 2 domain protein, B-cell linker protein, BASH, BLNK, BLNK-S, Cytoplasmic adapter protein, LY57, SLP-65, SLP65, Src homology 2 domain-containing leukocyte protein of 65 kDa, bca
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetBLNK
Short nameBLNK Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameB-cell linker (Antibody to)
Alternative techniqueantibodies
Alternative to gene target BLNK and IDBG-83724 and ENSG00000095585 and 29760, BT, Blnk and IDBG-165316 and ENSMUSG00000061132 and 17060, Plasma membranes, protein binding, this GO :0005068 and transmembrane receptor protein tyrosine kinase adaptor activity and molecular function this GO :0005070 and SH3/SH2 adaptor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005622 and intracellular and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006954 and inflammatory response and biological process this GO :0006959 and humoral immune response and biological process this GO :0007169 and transmembrane receptor protein tyrosine kinase signaling pathway and biological process this GO :0009967 and positive regulation of signal transduction and biological process this GO :0030183 and B cell differentiation and biological process this GO :0035556 and intracellular signal transduction and biological process, this GO :0005068: transmembrane receptor protein tyrosine kinase adaptor activity, this GO :0005068: transmembrane receptor protein tyrosine kinase adaptor activity and also this GO :0005070: SH3/SH2 adaptor activity and also this GO :0005515: protein binding, this GO :0005070: SH3/SH2 adaptor activity, this GO :0005515: protein binding, 24520 and IDBG-638042 and ENSBTAG00000021358 and 510393, B-cell linker
Identity 14211
Gene BLNK
Long gene name B-cell linker
Synonyms SLP65 Ly57 SLP-65 BLNK-s BASH bca
Synonyms name B-cell adapter containing a SH2 domain protein B-cell activation Src homology [SH2] domain-containing leukocyte protein of 65 kD B cell adaptor containing SH2 domain
Locus 10q24, 1
Discovery year 2001-07-16
GenBank acession AF068180
Entrez gene record 29760
Pubmed identfication 9697839 10583958
RefSeq identity NM_013314
Classification SH2 domain containing
Havana BLAST/BLAT OTTHUMG00000018827
Locus Specific Databases BLNKbase: Mutation registry for BLNK deficiency LRG_21

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