| Alternative name1 | Breast-Ovarian Cancer Susceptibility), Early Onset, phospyhorylated (Ser1423) (Breast Cancer 1, Anti-BRCA1 |
| Alternative name2 | Breast-Ovarian Cancer Susceptibility), Early Onset, phospyhorylated (Ser1423) (Breast Cancer 1, BRCA1 |
| Alternative name3 | Breast-Ovarian Cancer Susceptibility), Early Onset, phospyhorylated (Ser1423) (Breast Cancer 1, BRCA1 |
| Alternative name4 | phospyhorylated, BRCA1 |
| Alternative name5 | Breast-Ovarian Cancer Susceptibility), Early Onset, phospyhorylated (Ser1423) (Breast Cancer 1, Anti -BRCA1 |
| Other names | BRCA1/BRCA2-containing complex, Breast cancer type 1 susceptibility protein, OTTHUMP00000212143, OTTHUMP00000212147, OTTHUMP00000212148, OTTHUMP00000212149, OTTHUMP00000212150, OTTHUMP00000212151, OTTHUMP00000212155, RING finger protein 53, RING finger protein 53, breast and ovarian cancer susceptibility protein 1, breast and ovarian cancer sususceptibility protein, breast cancer 1, breast cancer type 1 susceptibility protein, early onset, subunit 1, BRCA1 |
| Gene name | N/A |
| Gene name synonims | N/A |
| Other gene names | BRCA1, BRCAI, BRCC1, BROVCA1, IRIS, PNCA4, PSCP, RNF53, RNF53, BRCA1 |
| Category | Antibodies |
| Clonality | Polyclonal |
| Immunoglobulin isotype | IgG |
| Clone | Polyclonal antibody |
| Host organism | Source: Human, Host: Rabbit |
| Species reactivity | Human |
| Specificity and cross-reactivity | Mr 200-220kD, Specificity was demonstrated by blocking the antibody with the immunizing peptide and treating the blot with lambda-phosphatase, Recognizes human phospho-BRCA1 (Ser1423) |
| Purification method | Affinity Purified by Protein A affinity chromatography |
| Form/Appearance | 0, 0, pH 7, 05% sodium azide before the addition of glycerol to 30%, 15M sodium chloride, 1M Tris glycine, 4, Supplied as a liquid in 0 |
| Concentration | N/A |
| Storage and shipping | Aliquots are stable for at least 12 months productone should be stored at -20 degrees Celsius, For long-term storage, For maximum recovery of product, For optimal long term storage, Further dilutions can be made in assay buffer, centrifuge the original vial after thawing and prior to removing the cap, productone should be kept at -20 degrees Celsius, Store at 4 degrees Celsius for short term storage |
| Tested for: | Western Blot (WB) |
| Description | Polyclonal antibodies generally are more stable and retain their reactivity under unfavorable conditions, Polyclonal antibodies have series of advantages - larger batches can be supplied at a time, Properly used, To obtain more detailed information on productone, please, refer to the full product datasheet, the time needed for production is considerably shorter, they are inexpensive to manufacture and respectively to buy, this antibody will ensure excellent and reproducible results with guaranteed success for the applications that it is tested in, productone is a polyclonal antibody of high purity and binding affinity for the antigen that it is risen against |
| Advisory | For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, avoid cycles of freezing and thawing, please, In order to retain the quality and the affinity of productone unchanged |
| Properties | C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS Polyclonals_1 they should be stored frozen at - 24° |
| Gene target | Breast-Ovarian Cancer Susceptibility), Early Onset, phospyhorylated (Ser1423) (Breast Cancer 1, BRCA1 |
| Short name | Breast-Ovarian Cancer Susceptibility) Antibody, Early Onset, phospyhorylated (Ser1423) (Breast Cancer 1, BRCA1 |
| Technique | antibodies against human proteins, antibodies for, Antibody |
| Alternative name | Breast-Ovarian Cancer Susceptibility) (Antibody to), Early Onset, early onset, phospyhorylated (Ser1423) (Breast Cancer 1, breast cancer 1 |
| Alternative technique | antibodies |
| Alternative to gene target | BRCA1 and IDBG-52172 and ENSG00000012048 and 672, BRCA1 and IDBG-640630 and ENSBTAG00000022520 and 353120, BRCAI and BRCC1 and BROVCA1 and IRIS and PNCA4 and PPP1R53 and PSCP and RNF53, Brca1 and IDBG-212218 and ENSMUSG00000017146 and 12189, DNA-templated and biological process this GO :0045893 and positive regulation of transcription, DNA-templated and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0046600 and negative regulation of centriole replication and biological process this GO :0046872 and metal ion binding and molecular function this GO :0050681 and androgen receptor binding and molecular function this GO :0051571 and positive regulation of histone H3-K4 methylation and biological process this GO :0051572 and negative regulation of histone H3-K4 methylation and biological process this GO :0051573 and negative regulation of histone H3-K9 methylation and biological process this GO :0051574 and positive regulation of histone H3-K9 methylation and biological process this GO :0051865 and protein autoubiquitination and biological process this GO :0070512 and positive regulation of histone H4-K20 methylation and biological process this GO :0070531 and BRCA1-A complex and cellular component this GO :0071158 and positive regulation of cell cycle arrest and biological process this GO :0071681 and cellular response to indole-3-methanol and biological process this GO :0085020 and protein K6-linked ubiquitination and biological process this GO :2000145 and regulation of cell motility and biological process this GO :2000617 and positive regulation of histone H3-K9 acetylation and biological process this GO :2000620 and positive regulation of histone H4-K16 acetylation and biological process, androgen receptor binding, early onset, nuclei, signal transduction by p53 class mediator resulting in transcription of p21 class mediator and biological process this GO :0007059 and chromosome segregation and biological process this GO :0007098 and centrosome cycle and biological process this GO :0008270 and zinc ion binding and molecular function this GO :0008274 and gamma-tubulin ring complex and cellular component this GO :0008630 and intrinsic apoptotic signaling pathway in response to DNA damage and biological process this GO :0009048 and dosage compensation by inactivation of X chromosome and biological process this GO :0010212 and response to ionizing radiation and biological process this GO :0015631 and tubulin binding and molecular function this GO :0016567 and protein ubiquitination and biological process this GO :0016874 and ligase activity and molecular function this GO :0019899 and enzyme binding and molecular function this GO :0030521 and androgen receptor signaling pathway and biological process this GO :0030529 and ribonucleoprotein complex and cellular component this GO :0031398 and positive regulation of protein ubiquitination and biological process this GO :0031436 and BRCA1-BARD1 complex and cellular component this GO :0031572 and G2 DNA damage checkpoint and biological process this GO :0031625 and ubiquitin protein ligase binding and molecular function this GO :0031941 and filamentous actin and cellular component this GO :0034446 and substrate adhesion-dependent cell spreading and biological process this GO :0035066 and positive regulation of histone acetylation and biological process this GO :0035067 and negative regulation of histone acetylation and biological process this GO :0042127 and regulation of cell proliferation and biological process this GO :0042981 and regulation of apoptotic process and biological process this GO :0043009 and chordate embryonic development and biological process this GO :0043234 and protein complex and cellular component this GO :0043627 and response to estrogen and biological process this GO :0044030 and regulation of DNA methylation and biological process this GO :0044212 and transcription regulatory region DNA binding and molecular function this GO :0045717 and negative regulation of fatty acid biosynthetic process and biological process this GO :0045739 and positive regulation of DNA repair and biological process this GO :0045892 and negative regulation of transcription, this GO :0000151 and ubiquitin ligase complex and cellular component this GO :0000724 and double-strand break repair via homolo this GO us recombination and biological process this GO :0000793 and condensed chromosome and cellular component this GO :0000794 and condensed nuclear chromosome and cellular component this GO :0001726 and ruffle and cellular component this GO :0003677 and DNA binding and molecular function this GO :0003684 and damaged DNA binding and molecular function this GO :0003713 and transcription coactivator activity and molecular function this GO :0003723 and RNA binding and molecular function this GO :0004842 and ubiquitin-protein transferase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005694 and chromosome and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005925 and focal adhesion and cellular component this GO :0006260 and DNA replication and biological process this GO :0006281 and DNA repair and biological process this GO :0006301 and postreplication repair and biological process this GO :0006302 and double-strand break repair and biological process this GO :0006349 and regulation of gene expression by genetic imprinting and biological process this GO :0006357 and regulation of transcription from RNA polymerase II promoter and biological process this GO :0006359 and regulation of transcription from RNA polymerase III promoter and biological process this GO :0006633 and fatty acid biosynthetic process and biological process this GO :0006915 and apoptotic process and biological process this GO :0006974 and cellular response to DNA damage stimulus and biological process this GO :0006978 and DNA damage response, this GO :0003677: DNA binding, this GO :0003677: DNA binding and also this GO :0003684: damaged DNA binding and also this GO :0003713: transcription coactivator activity and also this GO :0003723: RNA binding and also this GO :0004842: ubiquitin-protein transferase activity and also this GO :0005515: protein binding and also this GO :0008270: zinc ion binding and also this GO :0015631: tubulin binding and also this GO :0016874: ligase activity and also this GO :0019899: enzyme binding and also this GO :0031625: ubiquitin protein ligase binding and also this GO :0044212: transcription regulatory region DNA binding and also this GO :0046872: metal ion binding and also this GO :0050681: androgen receptor binding, this GO :0003684: damaged DNA binding, this GO :0003713: transcription coactivator activity, this GO :0003723: RNA binding, this GO :0004842: ubiquitin-protein transferase activity, this GO :0005515: protein binding, this GO :0008270: zinc ion binding, this GO :0015631: tubulin binding, this GO :0016874: ligase activity, this GO :0019899: enzyme binding, this GO :0031625: ubiquitin protein ligase binding, this GO :0044212: transcription regulatory region DNA binding, this GO :0046872: metal ion binding, this GO :0050681: androgen receptor binding, breast cancer 1 |
| Identity | 1100 |
| Gene | BRCA1 |
| Long gene name | BRCA1, DNA repair associated |
| Synonyms gene name | breast cancer 1, early onset breast cancer 1 |
| Synonyms | RNF53 BRCC1 PPP1R53 FANCS |
| Synonyms name | BRCA1/BRCA2-containing complex, complementation group S , regulatory subunit 53 Fanconi anemia, subunit 1 protein phosphatase 1 |
| Locus | 17q21, 31 |
| Discovery year | 1991-02-20 |
| GenBank acession | U14680 |
| Entrez gene record | 672 |
| Pubmed identfication | 1676470 25472942 |
| RefSeq identity | NM_007294 |
| Classification | Ring finger proteins Protein phosphatase 1 regulatory subunits BRCA1 A complex BRCA1 B complex BRCA1 C complex Fanconi anemia complementation groups |
| Havana BLAST/BLAT | OTTHUMG00000157426 |
| Locus Specific Databases | Breast Cancer BRCA1 database at LOVD-China LOVD - Leiden Open Variation Database LOVD - Leiden Open Variation Database LRG_292 |
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