c-Raf(Ser339) Antibody

c-Raf(Ser339) Antibody size: 0.1ml 281

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES

Price 281

Size 0.1ml

Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit

Long name	c-Raf(Ser339) Primary Polyclonal Antibody
Also known as	c-Raf(Ser339) PAb
Category	Primary Antibodies
Conjugation	Unconjugated
Target Antigen	c-Raf Ser339
Specificity	This is a highly specific antibody against c-Raf Ser339
Modification(s)	Phosphorylation
Modification site(s)	Ser339
Clonality	Polyclonal antibody
Clone number	Polyclonal antibody
Concentration	1ug per 1ul
Immunogen range	330-345/648
Subcellular location	Mitochondrion
Source	KLH conjugated synthetic phosphopeptide derived from human c-Raf around the phosphorylation site of Ser339
Gene ID number	5894
Swiss Prot	P04049
Tested Applications	IF(IHC-P), IHC-P, WB
Recommended dilutions	IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity	Mouse, Rat, Human
Cross reactive species details	not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen	ADCY5 and ADCY6, Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death, Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity, Phosphorylates TNNT2/cardiac muscle troponin T, Phosphorylates adenylyl cyclases: ADCY2, Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2), Regulates Rho signaling and migration, Restricts caspase activation in response to selected stimuli, The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, and erythroid differentiation, and is required for normal wound healing, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, apoptosis, apoptosis (MAP3K5/ASK1 and STK3/MST2), by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75', differentiation, notably Fas stimulation, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, pathogen-mediated macrophage apoptosis, proliferation and angiogenesis (RB1), resulting in their activation, survival and oncogenic transformation, which induces down-regulation of OCLN, Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade
Purification method	This antibody was purified via Protein A
Storage conditions	50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names	CMD1NN, CRAF, Proto-oncogene c-RAF, RAF, RAF proto-oncogene serine/threonine-protein kinase, RAF1, Raf-1, c-Raf, NS5
Properties	C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene target	c-Raf(Ser339)
Short name	c-Raf(Ser339) Antibody
Technique	antibodies against human proteins, antibodies for, Antibody
Alternative name	c-Raf(Ser339) (Antibody to)
Alternative technique	antibodies

c-Raf(Ser339) Antibody

c-Raf(Ser339) Antibody size: 0.1ml 281

Similar products

Subscribe to our Newsletter