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CD163 Antibody

CD163 Antibody size: 0.08 ml 199

Supplier NJS POLY
Price 199
Size 0.08 ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
CategoryAntibody
Concentration09% sodium azide, 4 with 0, In 1X PBS pH 7
FormPurified
ConjugationUnconjugated
ClonePolyclonal antibody
Recognised antigenCD163
Host animalRabbit (Oryctolagus cuniculus)
ClonalityPolyclonal (rabbit origin)
Species reactivity Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens)
Tested applications ELISA, IHC, WB
Recommended dilutionsIHC (Paraffin): 1:10-1:50, Western blot: 1:1000
NotesTitration of the CD163 antibody may be required due to differences in protocols and secondary/substrate sensitivity
Intented useThis CD163 antibodyis to be used only for research purposes and not for diagnostics
Uniprot #Q86VB7
PurityPurified
Description And it exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype, It also induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, It binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner, The protein may play a role in the uptake and recycling of iron, inositol triphosphate production and secretion of IL6 and CSF1, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme, CD163 is an acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage
ImmunogenA portion of amino acids 245-274 from the human protein was used as the immunogen for this CD163 antibody
Storage Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the CD163 antibody and store frozen at -20 deg
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°
Gene targetCD163
Short nameCD163 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameCD163 molecule (Antibody to)
Alternative techniqueantibodies
Alternative to gene target CD163 and IDBG-16292 and ENSG00000177575 and 9332, CD163 and IDBG-639861 and ENSBTAG00000019669 and 533844, Cd163 and IDBG-186721 and ENSMUSG00000008845 and 93671, Extracellular, M130 and MM130, protein binding, this GO :0005044 and scavenger receptor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005576 and extracellular region and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0006898 and receptor-mediated endocytosis and biological process this GO :0006953 and acute-phase response and biological process this GO :0016020 and membrane and cellular component this GO :0030666 and endocytic vesicle membrane and cellular component, this GO :0005044: scavenger receptor activity, this GO :0005044: scavenger receptor activity and also this GO :0005515: protein binding, this GO :0005515: protein binding, CD163 molecule
Identity 1631
Gene CD163
Long gene name CD163 molecule
Synonyms gene name CD163 antigen
Synonyms M130 MM130 SCARI1
Locus 12p13, 31
Discovery year 2000-01-18
GenBank acession Z22968
Entrez gene record 9332
Pubmed identfication 10403791 8370408
RefSeq identity NM_004244 NM_203416
Classification CD molecules Scavenger receptors
Havana BLAST/BLAT OTTHUMG00000168353

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