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CHK1 (AF7H4) Monoclonal Antibody

CHK1 (AF7H4) Monoclonal Antibody size: 0.1ml 362

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 362
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameCHK1 (AF7H4) Monoclonal Antibody
Also known asCHK1 (AF7H4) Monoclonal Antibody
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenCHK1
SpecificityThis is a highly specific antibody against CHK1
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityMonoclonal
Clone numberAF7H4
Concentration2ug/ul
SourceRecombinant human protein purified from E, coli (His-CHK1)
Gene ID number1111
Swiss ProtO14757
Tested Applications IP, WB
Recommended dilutions0 ug), 0 ug/ml) IP (2, WB (2
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Chk1 inhibitors can preferentially potentiate the efficacy of DNA damaging agents in cancer cells, Chk1 is an evolutionarily conserved protein kinase that functions to ensure genomic integrity upon genotoxic stress, Thus, When the G2 or S checkpoint is abrogated by the inhibition of Chk1, and Chk1 is an attractive therapeutic target for cancer treatment, especially since approximately 50% of all human cancers are p53-deficient, p53-deficient cancer cells undergo mitotic catastrophe and eventually apoptosis, whereas normal cells are still arrested in the G1 phase, Check point kinase 1 (Chk1) is a serine / threonine protein kinase and a key mediator in the DNA damage-induced checkpoint network
Purification methodPurified by Protein G
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names CHEK1, CHK1 checkpoint homolog, Cell cycle checkpoint kinase, Checkpoint kinase-1, Serine/threonine-protein kinase Chk1, CHK1
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
About Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones
Gene targetCHK1 (AF7H4) Monoclonal
Short nameCHK1 (AF7H4) Monoclonal Antibody
Technique Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody
Alternative nameCHK1 (AF7H4) monoclonal (Antibody to)
Alternative techniqueantibodies
Identity 1925
Gene CHEK1
Long gene name checkpoint kinase 1
Synonyms gene name CHK1 (checkpoint, S, pombe) , pombe) homolog CHK1 checkpoint homolog (S
Synonyms CHK1
Locus 11q24, 2
Discovery year 1998-04-21
GenBank acession AF016582 BC017575
Entrez gene record 1111
Pubmed identfication 9278511 9382850
RefSeq identity NM_001274
Havana BLAST/BLAT OTTHUMG00000165853

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