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CHN 1/Alpha-chimerin Antibody

CHN 1/Alpha-chimerin Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameCHN 1/Alpha-chimerin Primary Polyclonal Antibody
Also known asCHN 1/Alpha-chimerin PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenCHN 1/Alpha-chimerin
SpecificityThis is a highly specific antibody against CHN 1/Alpha-chimerin
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Alpha-chimerin
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Alpha1-chimaerin expression is down-regulated resulting in an increase in spine growth and dendritic branching, Alpha1-chimaerin plays a significant role in the regulation of dendritic growth during neuronal development, By inactivating Rac 1, In the presence of reduced neuronal activity, It is recruited to the plasma membrane by phospholipase C Beta-coupled cell surface receptors activating the downstream generation of DAG (diacylglycerol), Overexpression of Alpha1-chimaerin results in dendritic spine retraction and the loss of dendritic branches, The ?-chimaerin variant is a neuron-specific, This variant lacks the N-terminal SH2 domain that is present in the Alpha2 variant, diacylglycerol-binding and GTPase-activating protein for ras-related protein Rac 1, The Rac-GAP chimaerin family member Alpha-chimaerin (also known as N-chimaerin or rho GTPase-activating protein 2) has two splice variants: Alpha1 and Alpha2
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names ARHGAP2, Alpha-chimerin, CHIN_HUMAN, CHN, Chn1, N chimaerin, N chimerin, N-chimaerin, N-chimerin, NC, RHOGAP2, Rho GTPase-activating protein 2, A-chimaerin
Description- or alpha protein sometimes glycoprotein present in blood, The CHN 1/Alpha-chimerin Antibody is a &alpha
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetCHN 1/Alpha-chimerin
Short nameCHN 1/Alpha-chimerin Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameCHN 1/a-chimerin (Antibody to)
Alternative techniqueantibodies
Identity 1943
Gene CHN1
Long gene name chimerin 1
Synonyms gene CHN DURS2
Synonyms gene name Duane retraction syndrome 2 chimerin (chimaerin) 1
Synonyms RhoGAP2 ARHGAP2 n-chimerin
Synonyms name 2) chimaerin 1 , Chimerin 1 (GTPase-activating protein, rho
Locus 2q31, 1
Discovery year 1991-07-12
Entrez gene record 1123
Pubmed identfication 2299665 15013773 18653847
RefSeq identity NM_001822
Classification SH2 domain containing Rho GTPase activating proteins
Havana BLAST/BLAT OTTHUMG00000154225

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