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CISH Antibody

CISH Antibody size: 0.1mg 389

Supplier NJS POLY
Price 389
Size 0.1mg
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
CategoryAntibody
Concentration2ml sterile DI water, 5mg/ml if reconstituted with 0
FormAntigen affinity purified
ConjugationUnconjugated
ClonePolyclonal antibody
Recognised antigenCISH
Host animalRabbit (Oryctolagus cuniculus)
ClonalityPolyclonal (rabbit origin)
Species reactivity Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens)
Tested applications ICC, IHC-P, WB
Recommended dilutions5-1ug/ml, 5-1ug/ml, 5-1ug/ml, IHC (Paraffin): 0, Immunocytochemistry: 0, Western blot: 0
Notes Titration of the CISH antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts
Intented useThis CISH antibodyis to be used only for research purposes and not for diagnostics
Uniprot #Q9NSE2
PurityAntigen affinity
Description CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling, CIS-1, CISH controls interleukin-2 signaling, CISH expression was upregulated by lipopolysaccharide (LPS) or Cryptosporidium parvum exposure, G18, Gain- and loss-of-function studies showed that CISH accelerated degradation of IKBA and enhanced NFKB activation in cholangiocytes in response to LPS stimulation or C parvum exposure, SOCS, The human gene is mapped to chromosome 3p21, The mouse gene is tightly linked to the Gnai2 gene on chromosome 9, a region syntenic to human chromosome 3p21, also called CIS, and this upregulation involved downregulation of MIR98 and LET7, and variations of CISH with certain SNPs are associated with susceptibility to bacteremia, is an important negative regulator for inflammatory signaling and belongs to the suppressors of cytokine signaling (SOCS) family, tuberculosis and malaria, which relieved MIR98- and LET7-mediated translational repression of CISH, 3 by FISH, Cytokine inducible SH2-containing protein
Immunogen mouse and rat), Amino acids 241-258 (LPLPRRMADYLRQYPFQL) were used as the immunogen for this CISH antibody (100% homologous in human
Storage Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the CISH antibody can be stored for up to one month at 4oC, After reconstitution
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°
Gene targetCISH
Short nameCISH Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative namecytokine inducible SH2-containing protein (Antibody to)
Alternative techniqueantibodies
Alternative to gene target BACTS2 and CIS and CIS-1 and G18 and SOCS, CISH and IDBG-37175 and ENSG00000114737 and 1154, CISH and IDBG-645783 and ENSBTAG00000022622 and 616753, Cish and IDBG-197065 and ENSMUSG00000032578 and 12700, Plasma membranes, protein binding, this GO :0001558 and regulation of cell growth and biological process this GO :0003674 and molecular function and molecular function this GO :0005515 and protein binding and molecular function this GO :0005575 and cellular component and cellular component this GO :0005829 and cytosol and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0007205 and protein kinase C-activating G-protein coupled receptor signaling pathway and biological process this GO :0009968 and negative regulation of signal transduction and biological process this GO :0016567 and protein ubiquitination and biological process this GO :0035556 and intracellular signal transduction and biological process this GO :0045087 and innate immune response and biological process this GO :0060397 and JAK-STAT cascade involved in growth hormone signaling pathway and biological process, this GO :0003674: molecular_function, this GO :0003674: molecular_function and also this GO :0005515: protein binding, this GO :0005515: protein binding, cytokine inducible SH2-containing protein
Identity 1984
Gene CISH
Long gene name cytokine inducible SH2 containing protein
Synonyms gene name cytokine inducible SH2-containing protein
Synonyms CIS G18 CIS-1 SOCS
Locus 3p21, 2
Discovery year 1996-09-23
GenBank acession Z77852
Entrez gene record 1154
Pubmed identfication 9465889 7796808
RefSeq identity NM_145071
Classification Suppressors of cytokine signaling SH2 domain containing
Havana BLAST/BLAT OTTHUMG00000156853

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