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Complement Factor B Antibody / CFB

Complement Factor B Antibody / CFB size: 0.1mg 406

Supplier NJS POLY
Price 406
Size 0.1mg
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
CategoryAntibody
Concentration2ml sterile DI water, 5mg/ml if reconstituted with 0
FormAntigen affinity purified
ConjugationUnconjugated
ClonePolyclonal antibody
Recognised antigenComplement Factor B / CFB
Host animalRabbit (Oryctolagus cuniculus)
ClonalityPolyclonal (rabbit origin)
Species reactivity Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens)
Tested applications IHC-P, WB
Recommended dilutions1-0, 5-1ug/ml, 5ug/ml, IHC (FFPE): 0, Western blot: 0
NotesOptimal dilution of the Complement Factor B antibody should be determined by the researcher
Intented useThis Complement Factor B antibodyis to be used only for research purposes and not for diagnostics
Uniprot #P00751
PurityAntigen affinity
Description Bb is involved in the proliferation of preactivated B lymphocytes, Factor B circulates in the blood as a single chain polypeptide, Polymorphisms in this gene are associated with a reduced risk of age-related macular degeneration, The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase, The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2, This cluster includes several genes involved in regulation of the immune reaction, This gene encodes complement factor B, This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6, Upon activation of the alternative pathway, a component of the alternative pathway of complement activation, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb, while Ba inhibits their proliferation, Complement factor B is a protein that in humans is encoded by the CFB gene
ImmunogenAmino acids E518-L764 from the human protein were used as the immunogen for the Complement Factor B antibody
Storage Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the Complement Factor B antibody may be kept for up to one month refrigerated at +4 degrees C, After reconstitution, For long-term
LocalizationCytoplasmic
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°
Gene targetComplement Factor B / CFB
Short nameComplement Factor B Antibody / CFB
Technique antibodies against human proteins, antibodies for, Antibody
Alternative name Uncharacterized protein, cDNA FLJ55673, highly similar to Complement factor B, Complement Factor B (Antibody to) / Complement factor B Ba fragment
Alternative techniqueantibodies
Alternative to gene target CFB and IDBG-406598 and ENSG00000244255 and, Uncharacterized protein, cDNA FLJ55673, highly similar to Complement factor B, multiple, serine-type endopeptidase activity, this GO :0003824 and catalytic activity and molecular function this GO :0004252 and serine-type endopeptidase activity and molecular function this GO :0006508 and proteolysis and biological process, this GO :0003824: catalytic activity, this GO :0003824: catalytic activity and also this GO :0004252: serine-type endopeptidase activity, this GO :0004252: serine-type endopeptidase activity, Complement factor B Ba fragment
Identity 1037
Gene CFB
Long gene name complement factor B
Synonyms gene BFD BF
Synonyms gene name B-factor, properdin
Synonyms H2-Bf
Locus 6p21, 33
Discovery year 1986-01-01
GenBank acession L15702
Entrez gene record 629
RefSeq identity NM_001710
Classification Sushi domain containing Complement system
Havana BLAST/BLAT OTTHUMG00000031198
Locus Specific Databases LRG_136

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