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Complement Factor I Antibody / CFI

Complement Factor I Antibody / CFI size: 0.1mg 406

Supplier NJS POLY
Price 406
Size 0.1mg
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
CategoryAntibody
Concentration2ml sterile DI water, 5mg/ml if reconstituted with 0
FormAntigen affinity purified
ConjugationUnconjugated
ClonePolyclonal antibody
Recognised antigenComplement Factor I / CFI
Host animalRabbit (Oryctolagus cuniculus)
ClonalityPolyclonal (rabbit origin)
Species reactivity Due to limited knowledge and inability to test the antibody against all known species, Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens)
Tested applicationsWB
Recommended dilutions1-0, 5ug/ml, Western blot: 0
Intented useThis Factor I antibodyis to be used only for research purposes and not for diagnostics
Uniprot #P05156
PurityAntigen affinity
Description Defects in this gene cause complement factor I deficiency, Mutations in this gene have been associated with a predisposition to atypical hemolytic uremic syndrome, Primary glomerulonephritis with immune deposits and age-related macular degeneration are other conditions associated with mutations of this gene, The encoded preproprotein is cleaved to produce both heavy and light chains, This gene encodes a serine proteinase that is essential for regulating the complement cascade, This heterodimer can cleave and inactivate the complement components C4b and C3b, a disease characterized by acute renal failure, also known as C3b/C4b inactivator, an autosomal recessive disease associated with a susceptibility to pyogenic infections, and it prevents the assembly of the C3 and C5 convertase enzymes, is a protein that in humans is encoded by the CFI gene, microangiopathic hemolytic anemia and thrombocytopenia, which are linked by disulfide bonds to form a heterodimeric glycoprotein, Complement factor I
ImmunogenAmino acids K19-D220 were used as the immunogen for the Factor I antibody
Storage Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the Factor I antibody may be kept for up to one month refrigerated at +4 degrees C, After reconstitution, For long-term
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°
Gene targetComplement Factor I / CFI
Short nameComplement Factor I Antibody / CFI
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameComplement Factor I (Antibody to) / complement factor I
Alternative techniqueantibodies
Alternative to gene target AHUS3 and ARMD13 and C3b-INA and C3BINA and FI and IF and KAF, BT, CFI and IDBG-33966 and ENSG00000205403 and 3426, Cfi and IDBG-193652 and ENSMUSG00000058952 and 12630, classical pathway and biological process this GO :0016020 and membrane and cellular component this GO :0030449 and regulation of complement activation and biological process this GO :0045087 and innate immune response and biological process this GO :0046872 and metal ion binding and molecular function this GO :0070062 and extracellular vesicular exosome and cellular component, metal ion binding, nuclei, this GO :0003824 and catalytic activity and molecular function this GO :0004252 and serine-type endopeptidase activity and molecular function this GO :0005044 and scavenger receptor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005576 and extracellular region and cellular component this GO :0005615 and extracellular space and cellular component this GO :0005634 and nucleus and cellular component this GO :0006508 and proteolysis and biological process this GO :0006898 and receptor-mediated endocytosis and biological process this GO :0006958 and complement activation, this GO :0003824: catalytic activity, this GO :0003824: catalytic activity and also this GO :0004252: serine-type endopeptidase activity and also this GO :0005044: scavenger receptor activity and also this GO :0005515: protein binding and also this GO :0046872: metal ion binding, this GO :0004252: serine-type endopeptidase activity, this GO :0005044: scavenger receptor activity, this GO :0005515: protein binding, this GO :0046872: metal ion binding, 64790 and IDBG-640204 and ENSBTAG00000034501 and 513197, complement factor I
Identity 5394
Gene CFI
Long gene name complement factor I
Synonyms gene IF
Synonyms gene name I factor (complement)
Synonyms FI C3b-INA KAF
Synonyms name Konglutinogen-activating factor C3b-inactivator
Locus 4q25
Discovery year 1986-01-01
GenBank acession J02770
Entrez gene record 3426
Pubmed identfication 2956252
RefSeq identity NM_000204
Classification Complement system
Havana BLAST/BLAT OTTHUMG00000161109
Locus Specific Databases CFIbase: Mutation registry for Factor I deficiency (previously known as IFbase) LRG_48

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