| Long name | CSF1R (Tyr723) Primary Polyclonal Antibody |
| Also known as | CSF1R (Tyr723) PAb |
| Category | Primary Antibodies |
| Conjugation | Unconjugated |
| Target Antigen | CSF1R Tyr723 |
| Specificity | This is a highly specific antibody against CSF1R Tyr723 |
| Modification(s) | Phosphorylation |
| Modification site(s) | Tyr723 |
| Clonality | Polyclonal antibody |
| Clone number | Polyclonal antibody |
| Concentration | 1ug per 1ul |
| Immunogen range | 694-744/972 |
| Subcellular location | Cytoplasm |
| Source | KLH conjugated synthetic phosphopeptide derived from human CSF1R around the phosphorylation site of tyrosine 723 |
| Gene ID number | 1436 |
| Swiss Prot | P07333 |
| Tested Applications | IF(ICC), IF(IHC-P), IHC-P, WB |
| Recommended dilutions | IF(ICC)(1:50-200), IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity | Dog, Mouse, Rat, Human |
| Cross reactive species details | not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen | CD115 is expressed by cells of the monocytic lineage and by progenitor cells, Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation, Mutations in this gene have been associated with a predisposition to myeloid malignancy, The encoded protein is a member of the CSF1/PDGF receptor family of tyrosine protein kinases and contains 5 immunoglobulin like C2 type domains, This receptor mediates most if not all of the biological effects of this cytokine, a cytokine which controls the production, and function of macrophages, differentiation, This protein tyrosine kinase transmembrane receptor is the receptor for colony stimulating factor 1 |
| Purification method | This antibody was purified via Protein A |
| Storage conditions | 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names | C-FMS, CD115, CSF-1 receptor, CSF-1-R, CSF-1R, CSF1R, CSFR, FIM2, HDLS, M-CSF-R, Macrophage colony-stimulating factor 1 receptor, Proto-oncogene c-Fms, FMS |
| Properties | C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target | CSF1R (Tyr723) |
| Short name | CSF1R (Tyr723) Antibody |
| Technique | antibodies against human proteins, antibodies for, Antibody |
| Alternative name | colony stimulating factor 1 receptor (Tyr723) (Antibody to) |
| Alternative technique | antibodies |
| Alternative to gene target | C-FMS and CD115 and CSF-1R and CSFR and FIM2 and FMS and HDLS and M-CSF-R, CSF1R and IDBG-53268 and ENSG00000182578 and 1436, CSF1R and IDBG-646265 and ENSBTAG00000012771 and 509418, Cell surfaces, Csf1r and IDBG-150998 and ENSMUSG00000024621 and 12978, this GO :0001934 and positive regulation of protein phosphorylation and biological process this GO :0004672 and protein kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0004714 and transmembrane receptor protein tyrosine kinase activity and molecular function this GO :0005011 and macrophage colony-stimulating factor receptor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005886 and plasma membrane and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0006468 and protein phosphorylation and biological process this GO :0006954 and inflammatory response and biological process this GO :0007165 and signal transduction and biological process this GO :0007169 and transmembrane receptor protein tyrosine kinase signaling pathway and biological process this GO :0007275 and multicellular organismal development and biological process this GO :0008283 and cell proliferation and biological process this GO :0008284 and positive regulation of cell proliferation and biological process this GO :0008360 and regulation of cell shape and biological process this GO :0009986 and cell surface and cellular component this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0016772 and transferase activity, this GO :0004672: protein kinase activity, this GO :0004672: protein kinase activity and also this GO :0004713: protein tyrosine kinase activity and also this GO :0004714: transmembrane receptor protein tyrosine kinase activity and also this GO :0005011: macrophage colony-stimulating factor receptor activity and also this GO :0005515: protein binding and also this GO :0005524: ATP binding and also this GO :0016772: transferase activity, this GO :0004713: protein tyrosine kinase activity, this GO :0004714: transmembrane receptor protein tyrosine kinase activity, this GO :0005011: macrophage colony-stimulating factor receptor activity, this GO :0005515: protein binding, this GO :0005524: ATP binding, this GO :0016772: transferase activity, this GO :0019903: protein phosphatase binding, this GO :0019955: cytokine binding, this GO :0042803: protein homodimerization activity, transferase activity, transferring phosphorus-containing groups, transferring phosphorus-containing groups and also this GO :0019903: protein phosphatase binding and also this GO :0019955: cytokine binding and also this GO :0042803: protein homodimerization activity, transferring phosphorus-containing groups and molecular function this GO :0018108 and peptidyl-tyrosine phosphorylation and biological process this GO :0019221 and cytokine-mediated signaling pathway and biological process this GO :0019903 and protein phosphatase binding and molecular function this GO :0019955 and cytokine binding and molecular function this GO :0030097 and hemopoiesis and biological process this GO :0030224 and monocyte differentiation and biological process this GO :0030225 and macrophage differentiation and biological process this GO :0030316 and osteoclast differentiation and biological process this GO :0030335 and positive regulation of cell migration and biological process this GO :0031529 and ruffle organization and biological process this GO :0036006 and cellular response to macrophage colony-stimulating factor stimulus and biological process this GO :0038145 and macrophage colony-stimulating factor signaling pathway and biological process this GO :0042517 and positive regulation of tyrosine phosphorylation of Stat3 protein and biological process this GO :0042803 and protein homodimerization activity and molecular function this GO :0043235 and receptor complex and cellular component this GO :0045087 and innate immune response and biological process this GO :0045124 and regulation of bone resorption and biological process this GO :0045217 and cell-cell junction maintenance and biological process this GO :0046488 and phosphatidylinositol metabolic process and biological process this GO :0046777 and protein autophosphorylation and biological process this GO :0048015 and phosphatidylinositol-mediated signaling and biological process this GO :0060603 and mammary gland duct morphogenesis and biological process this GO :0061098 and positive regulation of protein tyrosine kinase activity and biological process this GO :0070374 and positive regulation of ERK1 and ERK2 cascade and biological process this GO :0071345 and cellular response to cytokine stimulus and biological process this GO :0071902 and positive regulation of protein serine/threonine kinase activity and biological process this GO :0090197 and positive regulation of chemokine secretion and biological process this GO :2000147 and positive regulation of cell motility and biological process this GO :2000249 and regulation of actin cytoskeleton reorganization and biological process, colony stimulating factor 1 receptor |
| Identity | 2433 |
| Gene | CSF1R |
| Long gene name | colony stimulating factor 1 receptor |
| Synonyms gene | FMS |
| Synonyms gene name | McDonough feline sarcoma viral (v-fms) oncogene homolog |
| Synonyms | C-FMS CSFR CD115 |
| Locus | 5q32 |
| Discovery year | 2001-06-22 |
| GenBank acession | U63963 |
| Entrez gene record | 1436 |
| Pubmed identfication | 1611909 |
| RefSeq identity | NM_005211 |
| Classification | Immunoglobulin like domain containing CD molecules Receptor Tyrosine Kinases |
| Havana BLAST/BLAT | OTTHUMG00000130050 |
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