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Dab1 (Tyr232) Antibody

Dab1 (Tyr232) Antibody size: 0.1ml 281

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 281
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameDab1 (Tyr232) Primary Polyclonal Antibody
Also known asDab1 (Tyr232) PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenDab1 Tyr232
Specificity Rat, This phosphorylation site is found at Tyr232 in Mouse, and Bovine DAB1, This is a highly specific antibody against Dab1 Tyr232
Modification(s)Phosphorylation
Modification site(s)Tyr232
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range210-260/588
Subcellular location Cell membrane, Cytoplasm
SourceKLH conjugated synthetic phosphopeptide derived from human Dab1 around the phosphorylation site of Tyr232
Gene ID number1600
Swiss ProtO75553
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Dab1 also mediates activation of Akt (PKB) by reelin resulting in inhibition of glycogen synthase kinase 3 beta (GSK-3 beta) and decreased phosphorylation of the microtubule-associated protein, Dab1 contains a phosphotyrosine binding (PTB) domain in the amino terminus, Dab1 is an intracellular adapter protein that functions in downstream signaling events initiated by the secreted protein reelin, Dab1 serine 491 is phosphorylated in a Cdk5-dependent manner and regulates, Phenotypically, Reelin-induced signaling during neural cortex development, Src family kinase and c-Abl activities are themselves then stimulated by binding to tyrosine phosphorylated Dab1, Tau, Tyrosine phosphorylation of Dab1 is increased by reelin binding to the Very Low Density Lipoprotein Receptor (VLDLR) and Apolipoprotein E Receptor 2 (ApoER2) through stimulation of Src family kinases, and severe cerebellar hypoplasia, disruption of neuronal migration, likely indirectly, the mutation of this gene produces motor defects and ataxia, Disabled 1 (Dab1) is an 80 kDa protein that is encoded by the Disabled-1 gene locus which is mutated in scrambler and yotari mutant mice
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names DAB1, Disabled homolog 1
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetDab1 (Tyr232)
Short nameDab1 (Tyr232) Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative namedisabled homolog 1 (Drosophila) (Tyr232) (Antibody to)
Alternative techniqueantibodies

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