| Alternative name1 | DNA Joinase, DNA Ligase IV ATP Dependent, DNA Repair Enzyme, LIG4, Ligase IV, Ligase IV DNA ATP Dependent, Polydeoxyribonucleotide Synthase [ATP] 4, Polynucleotide Ligase, Sealase), Anti-DNA Ligase IV (DNA Ligase 4 |
| Alternative name2 | DNA Joinase, DNA Ligase IV ATP Dependent, DNA Repair Enzyme, LIG4, Ligase IV, Ligase IV DNA ATP Dependent, Polydeoxyribonucleotide Synthase [ATP] 4, Polynucleotide Ligase, Sealase), DNA Ligase IV (DNA Ligase 4 |
| Alternative name3 | DNA Joinase, DNA Ligase IV ATP Dependent, DNA Repair Enzyme, LIG4, Ligase IV, Ligase IV DNA ATP Dependent, Polydeoxyribonucleotide Synthase [ATP] 4, Polynucleotide Ligase, Sealase), DNA Ligase IV (DNA Ligase 4 |
| Alternative name4 | DNA Ligase IV |
| Alternative name5 | DNA Joinase, DNA Ligase IV ATP Dependent, DNA Repair Enzyme, LIG4, Ligase IV, Ligase IV DNA ATP Dependent, Polydeoxyribonucleotide Synthase [ATP] 4, Polynucleotide Ligase, Sealase), Anti -DNA Ligase IV (DNA Ligase 4 |
| Other names | ATP-dependent, DNA, DNA joinase, DNA ligase 4, DNA ligase 4, DNA ligase IV, DNA ligase IV, DNA repair enzyme, OTTHUMP00000018690, Polydeoxyribonucleotide synthase [ATP] 4, ligase IV, polydeoxyribonucleotide synthase [ATP] 4, polynucleotide ligase, sealase, DNA ligase 4 |
| Gene name | N/A |
| Gene name synonims | N/A |
| Other gene names | LIG4, LIG4, N/A, LIG4 |
| Category | Antibodies |
| Clonality | Polyclonal |
| Immunoglobulin isotype | N/A |
| Clone | Polyclonal antibody |
| Host organism | Source: Human, Host: Rabbit |
| Species reactivity | Human |
| Specificity and cross-reactivity | Species Crossreactivity: Human |
| Purification method | Affinity Purified by Protein A affinity chromatography |
| Form/Appearance | PBS with 2% sucrose |
| Concentration | N/A |
| Storage and shipping | Aliquots are stable for at least 3 months productone should be stored at -20 degrees Celsius, For long-term storage and to avoid repeated freezing and thawing, For maximum recovery of product, Further dilutions can be made in assay buffer, add sterile glycerol (40-50%), aliquot and For optimal long term storage, centrifuge the original vial after thawing and prior to removing the cap, productone should be kept at -20 degrees Celsius, Store at 4 degrees Celsius for short term storage |
| Tested for: | Immunohistochemistry (IHC), Western Blot (WB), ELISA (EL/EIA) |
| Description | Activating enzymes will cut off the domain that is biological active to become functional, If the substrate is DNA they are called restriction enzymes, Enzymes are cleaving the substrate |
| Advisory | For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, avoid cycles of freezing and thawing, please, In order to retain the quality and the affinity of productone unchanged |
| Properties | C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS Polyclonals_1 they should be stored frozen at - 24° |
| Gene target | DNA Joinase, DNA Ligase IV ATP Dependent, DNA Repair LIG4, Ligase IV, Ligase IV DNA ATP Dependent, Polydeoxyribonucleotide Synthase [ATP] 4, Polynucleotide Ligase, Sealase), DNA Ligase IV (DNA Ligase 4 |
| Short name | DNA Joinase, DNA Ligase IV ATP Dependent, DNA Repair Enzyme, LIG4, Ligase IV, Ligase IV DNA ATP Dependent, Polydeoxyribonucleotide Synthase [ATP] 4, Polynucleotide Ligase, Sealase) Antibody, DNA Ligase IV (DNA Ligase 4 |
| Technique | antibodies against human proteins, antibodies for, enzymes, Antibody |
| Alternative name | Desoxyribonucleic acid, Desoxyribonucleic acid Joinase, Desoxyribonucleic acid Ligase IV adenosine triphosphate Dependent, Desoxyribonucleic acid Repair Enzyme, Ligase IV, Ligase IV Desoxyribonucleic acid adenosine triphosphate Dependent, Polydeoxyribonucleotide Synthase [adenosine triphosphate] 4, Polynucleotide Ligase, Sealase) (Antibody to), adenosine triphosphate-dependent, ligase IV, Desoxyribonucleic acid Ligase IV (Desoxyribonucleic acid Ligase 4 |
| Alternative technique | antibodies |
| Alternative to gene target | ATP-dependent, DNA, DNA gap filling and biological process this GO :0006302 and double-strand break repair and biological process this GO :0006303 and double-strand break repair via nonhomolo this GO us end joining and biological process this GO :0006310 and DNA recombination and biological process this GO :0007049 and cell cycle and biological process this GO :0007417 and central nervous system development and biological process this GO :0008022 and protein C-terminus binding and molecular function this GO :0008283 and cell proliferation and biological process this GO :0010165 and response to X-ray and biological process this GO :0010212 and response to ionizing radiation and biological process this GO :0010332 and response to gamma radiation and biological process this GO :0016032 and viral process and biological process this GO :0016874 and ligase activity and molecular function this GO :0032807 and DNA ligase IV complex and cellular component this GO :0033077 and T cell differentiation in thymus and biological process this GO :0033151 and V(D)J recombination and biological process this GO :0033152 and immunoglobulin V(D)J recombination and biological process this GO :0033153 and T cell receptor V(D)J recombination and biological process this GO :0035019 and somatic stem cell maintenance and biological process this GO :0043524 and negative regulation of neuron apoptotic process and biological process this GO :0045190 and isotype switching and biological process this GO :0046872 and metal ion binding and molecular function this GO :0048146 and positive regulation of fibroblast proliferation and biological process this GO :0050769 and positive regulation of neurogenesis and biological process this GO :0051102 and DNA ligation involved in DNA recombination and biological process this GO :0051103 and DNA ligation involved in DNA repair and biological process this GO :0051276 and chromosome organization and biological process this GO :0051301 and cell division and biological process this GO :0051402 and neuron apoptotic process and biological process this GO :0070419 and nonhomolo this GO us end joining complex and cellular component this GO :0071285 and cellular response to lithium ion and biological process this GO :0071897 and DNA biosynthetic process and biological process this GO :0075713 and establishment of integrated proviral latency and biological process, LIG4 and IDBG-49744 and ENSG00000174405 and 3981, LIG4 and IDBG-633610 and ENSBTAG00000015868 and 781252, LIG4S, Lig4 and IDBG-131943 and ENSMUSG00000049717 and 319583, metal ion binding, nuclei, this GO :0000012 and single strand break repair and biological process this GO :0000793 and condensed chromosome and cellular component this GO :0001701 and in utero embryonic development and biological process this GO :0002328 and pro-B cell differentiation and biological process this GO :0003677 and DNA binding and molecular function this GO :0003909 and DNA ligase activity and molecular function this GO :0003910 and DNA ligase (ATP) activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005925 and focal adhesion and cellular component this GO :0005958 and DNA-dependent protein kinase-DNA ligase 4 complex and cellular component this GO :0006266 and DNA ligation and biological process this GO :0006273 and lagging strand elongation and biological process this GO :0006281 and DNA repair and biological process this GO :0006297 and nucleotide-excision repair, this GO :0003677: DNA binding, this GO :0003677: DNA binding and also this GO :0003909: DNA ligase activity and also this GO :0003910: DNA ligase (ATP) activity and also this GO :0005515: protein binding and also this GO :0005524: ATP binding and also this GO :0008022: protein C-terminus binding and also this GO :0016874: ligase activity and also this GO :0046872: metal ion binding, this GO :0003909: DNA ligase activity, this GO :0003910: DNA ligase (ATP) activity, this GO :0005515: protein binding, this GO :0005524: ATP binding, this GO :0008022: protein C-terminus binding, this GO :0016874: ligase activity, this GO :0046872: metal ion binding, ligase IV |
| Identity | 6601 |
| Gene | LIG4 |
| Long gene name | DNA ligase 4 |
| Synonyms gene name | ATP-dependent , DNA, ligase IV |
| Synonyms name | polydeoxyribonucleotide synthase [ATP] 4 polynucleotide ligase sealase DNA repair enzyme DNA joinase |
| Locus | 13q33, 3 |
| Discovery year | 1995-08-10 |
| GenBank acession | X83441 |
| Entrez gene record | 3981 |
| Pubmed identfication | 7760816 |
| RefSeq identity | NM_002312 |
| Classification | DNA ligases |
| Havana BLAST/BLAT | OTTHUMG00000017328 |
| Locus Specific Databases | LIG4base: Mutation registry for LIG4 syndrome LRG_79 |
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