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DOCK3 Antibody

DOCK3 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameDOCK3 Primary Polyclonal Antibody
Also known asDOCK3 PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenDOCK3
SpecificityThis is a highly specific antibody against DOCK3
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human DOCK3
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Analysis of ectopic expression suggests that MOCA may affect the function of small GTPases involved in the regulation of Actin cytoskeleton or cell adhesion receptors, MOCA interacts with Presenilin proteins and has the ability to stimulate Tau phosphorylation suggesting that MOCA may be involved in Alzheimer disease, MOCA is also thought to be a guanine nucleotide exchange factor (GEF) which activates small GTPases by exchanging bound GDP for free GTP, MOCA is localized to the neuropil, MOCA is present in neurofibrillary tangles, also known as Presenilin-binding protein (PBP) or dedicator of cytokinesis protein 3 (DOCK3), and sometimes in pyramidal cells, in normal brains, is a 2030 amino acid cytoplasmic protein belonging to the DOCK family, while in Alzheimer disease brains, MOCA (modifier of cell adhesion)
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names DOCK 3, DOCK3_HUMAN, MOCA, Modier of cell adhesion, Presenilin binding protein, Dedicator of cytokinesis protein 3
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetDOCK3
Short nameDOCK3 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative namededicator on cytokinesis 3 (Antibody to)
Alternative techniqueantibodies
Alternative to gene target Cytoplasm, DOCK3 and IDBG-37292 and ENSG00000088538 and 1795, DOCK3 and IDBG-645771 and ENSBTAG00000001874 and 524692, Dock3 and IDBG-196849 and ENSMUSG00000039716 and 208869, MOCA and PBP, SH3 domain binding, this GO :0005085 and guanyl-nucleotide exchange factor activity and molecular function this GO :0005488 and binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0007264 and small GTPase mediated signal transduction and biological process this GO :0017124 and SH3 domain binding and molecular function this GO :0043547 and positive regulation of GTPase activity and biological process, this GO :0005085: guanyl-nucleotide exchange factor activity, this GO :0005085: guanyl-nucleotide exchange factor activity and also this GO :0005488: binding and also this GO :0005515: protein binding and also this GO :0017124: SH3 domain binding, this GO :0005488: binding, this GO :0005515: protein binding, this GO :0017124: SH3 domain binding, dedicator of cytokinesis 3
Identity 2989
Gene DOCK3
Long gene name dedicator of cytokinesis 3
Synonyms gene name dedicator of cyto-kinesis 3
Synonyms KIAA0299 MOCA PBP
Locus 3p21, 2
Discovery year 1998-05-13
GenBank acession AB002297
Entrez gene record 1795
Pubmed identfication 9205841
RefSeq identity NM_004947
Havana BLAST/BLAT OTTHUMG00000156892

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