DPYD Antibody, HRP Conjugated

DPYD Antibody, HRP Conjugated size: 0.1ml 350

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1

Price 350

Size 0.1ml

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Long name	HRP Conjugated, DPYD Polyclonal Antibody
Category	Conjugated Primary Antibodies
Conjugation	HRP Conjugated
Host Organism	Rabbit (Oryctolagus cuniculus)
Target Antigen	DPYD
Specificity	This is a highly specific antibody against DPYD
Modification	Unmodified
Modification site	None
Clonality	Polyclonal
Clone	Polyclonal antibody
Concentration	1ug per 1ul
Source	KLH conjugated synthetic peptide derived from human DPYD
Gene ID number	1806
Tested applications	IHC-P, WB
Recommended dilutions	IHC-P(1:100-500), WB(1:100-1000)
Crossreactivity	Mouse, Rat, Human
Crossreactive species details	not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background	Abnormal concentrations of these metabolites in bodily fluids may be the cause of neurological disease and a contraindication for treatment of cancer patients with certain pyrimidine analogs, DPYD also catalyzes the anticancer agent 5-fluorouracil (5-FU) pathway and is involved in the efficacy and toxicity of 5-FU, DPYD deficiency is a disease characterized by persistent urinary excretion of excessive amounts of uracil, Deficient DPYD alleles may constitute a risk factor for severe toxicity following treatment with 5-FU, Leukopenia, Patients suffering from this disease show a severe reaction to the anticancer drug 5-fluorouracil, Specifically, This reaction includes stomatitis, Variations in DPYD concentration may arise from alterations at the transcriptional level of the dihydropyrimidine dehydrogenase gene, a deficiency of DPYD leads to an accumulation of uracil and thymine, also known as hereditary thymine-uraciluria or familial pyrimidinemia, and neurologic symptoms, cerebellar ataxia, diarrhea, fever, hair loss, hypermethylation of the DPYD promoter downregulates dihydropyrimidine dehydrogenase expression, marked weight loss, progressing to semicoma, thrombocytopenia, thus, thymine and 5-hydroxymethyluracil, Dihydropyrimidine dehydrogenase (DPYD) catalyzes the first rate-limiting step of the NADPH-dependent catabolism of uracil and thymine to dihydrouracil and dihydrothymine, Involvement in disease:Defects in DPYD are the cause of dihydropyrimidine dehydrogenase deficiency (DPYD deficiency)
Purification method	This antibody was purified via Protein A
Storage conditions	50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% Gentamicin, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation Emission	N/A
Synonyms	DPD
Properties	Also monoclonal HRP conjugates are often used for Western Blot, HRP conjugates are often primary rabbit polyclonal antibodies couples to the , found in the roots of , (HRP), C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°, enzyme , horseradish, horseradish peroxidase
Gene target	DPYD Conjugated
Short name	Conjugated, DPYD Antibody
Technique	antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
Label	HRP
Alternative name	horseradish peroxidase coupled, DPYD (Antibody to)
Alternative technique	antibodies
Identity	3012
Gene	DPYD
Long gene name	dihydropyrimidine dehydrogenase
Locus	1p21, 3
Discovery year	1994-07-07
GenBank acession	U20938
Entrez gene record	1806
Pubmed identfication	7713523
RefSeq identity	NM_000110
Havana BLAST/BLAT	OTTHUMG00000039683
Locus Specific Databases	UMD Locus Specific Databases LRG_722

DPYD Antibody, HRP Conjugated

DPYD Antibody, HRP Conjugated size: 0.1ml 350

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