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FAK1 Antibody

FAK1 Antibody size: 0.1ml 354

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 354
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameFAK1 Primary Polyclonal Antibody
Also known asFAK1 PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenFAK1
SpecificityThis is a highly specific antibody against FAK1
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Source a, 706-1052), Recombinant human protein purified from E, a, coli (His-Fak1
Gene ID number5747
Swiss ProtQ05397
Tested Applications IP, WB
Recommended dilutions000) IP (2 ul), WB (1:5
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen ARHGEF7, EPHA2, Forms multisubunit signaling complexes with SRC and SRC family members upon activation, Functions in integrin signal transduction, G-protein coupled receptors (GPCR), GRB7, MAPK3/ERK1 and the MAP kinase signaling cascade, P53/TP53 ubiquitination and proteasomal degradation, Phosphorylates ACTN1, Phosphorylates SRC, Plays a role in osteogenesis and differentiation of osteoblasts, Promotes activation of MAPK1/ERK2, Promotes activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascade, Promotes localized and transient activation of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), RET and WASL, Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, Regulates axon growth and neuronal cell migration, Regulates numerous signaling pathways, Required for early embryonic development and placenta development, Required for embryonic angiogenesis, Signaling via CAS family members mediates activation of RAC1, adhesion, and normal heart development, and thereby modulates the activity of Rho family GTPases, and thereby regulates P53/TP53 activity, axon branching and synapse formation, but also in signaling downstream of numerous growth factor receptors, cell cycle progression, cell proliferation and apoptosis, creating binding sites for scaffold proteins, effectors and substrates, formation and disassembly of focal adhesions and cell protrusions, netrin receptors and LDL receptors, normal cardiomyocyte migration and proliferation, reorganization of the actin cytoskeleton, required for normal development of the nervous system, spreading, this increases SRC kinase activity, this leads to the phosphorylation of additional tyrosine residues, Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names FADK, FADK 1, FAK1, FRNK, Focal adhesion kinase 1, Focal adhesion kinase-related nonkinase, PPP1R71, PTK2, Protein phosphatase 1 regulatory subunit 71, Protein-tyrosine kinase 2, p125FAK, pp125FAK, FAK
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetFAK1
Short nameFAK1 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameFAK1 (Antibody to)
Alternative techniqueantibodies
Identity 9611
Gene PTK2
Long gene name protein tyrosine kinase 2
Synonyms gene name PTK2 protein tyrosine kinase 2
Synonyms FAK FADK FAK1 PPP1R71
Synonyms name protein phosphatase 1, regulatory subunit 71
Locus 8q24, 3
Discovery year 1992-10-02
GenBank acession L13616
Entrez gene record 5747
Pubmed identfication 8422239
RefSeq identity NM_005607
Classification Protein phosphatase 1 regulatory subunits FERM domain containing
Havana BLAST/BLAT OTTHUMG00000067438

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