Filters

FHIT Antibody

FHIT Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameFHIT Primary Polyclonal Antibody
Also known asFHIT PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenFHIT
SpecificityThis is a highly specific antibody against FHIT
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range47-72/147
Subcellular location Mitochondrion, Nucleus, Cytoplasm
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human FHIT
Gene ID number2272
Swiss ProtP49789
Tested Applications IF(IHC-P), IHC-P
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Can also hydrolyze P(1)-P(4)-bis(5'-adenosyl) tetraphosphate (Ap4A), Functions as tumor suppressor, Induction of apoptosis depends on the ability of FHIT to bind P(1)-P(3)-bis(5'-adenosyl) triphosphate or related compounds, Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptosis, Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival, Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways, but does not require its catalytic activity, but has extremely low activity with ATP, enhancing mitochondrial calcium uptake, it may in part come from the mitochondrial form, such as CCND1 and BIRC5, which sensitizes the low-affinity Ca(2+) transporters, Cleaves P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names AP3A hydrolase, AP3Aase, Bis(5'-adenosyl)-triphosphatase, Diadenosine 5', Dinucleosidetriphosphatase, FHIT, Fragile histidine triad protein, 5'''-P1, FRA3B, P3-triphosphate hydrolase
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetFHIT
Short nameFHIT Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameFHIT (Antibody to)
Alternative techniqueantibodies
Identity 3701
Gene FHIT
Long gene name fragile histidine triad
Synonyms gene name fragile histidine triad gene
Synonyms FRA3B AP3Aase
Locus 3p14, 2
Discovery year 1996-10-18
GenBank acession BC032336
Entrez gene record 2272
Pubmed identfication 8598045 9671749 26181368
RefSeq identity NM_002012
Havana BLAST/BLAT OTTHUMG00000158591

Similar products

Subscribe to our Newsletter