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GEF H1 Antibody

GEF H1 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameGEF H1 Primary Polyclonal Antibody
Also known asGEF H1 PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenGEF H1
SpecificityThis is a highly specific antibody against GEF H1
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range12-62/986
Subcellular location Cell membrane, Cytoplasm
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human GEF H1
Gene ID number9181
Swiss ProtQ92974
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Binds Rac-GTPases, Contributes to the tyrosine phosphorylation of RIPK2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2, Forms an intracellular sensing system along with NOD1 for the detection of microbial effectors during cell invasion by pathogens, Inactive toward CDC42, Involved in innate immune signaling transduction pathway promoting cytokine IL6/interleukin-6 and TNF-alpha secretion in macrophage upon stimulation by bacterial peptidoglycans, Involved not only in sensing peptidoglycan (PGN)-derived muropeptides through NOD1 that is independent of its GEF activity, May be involved in epithelial barrier permeability, May stimulate instead the cortical activity of Rac, Required for RHOA and RIP2 dependent NF-kappaB signaling pathways activation upon S, TC10, acts as a signaling intermediate between NOD2 receptor and RIPK2 kinase, and cancer, antigen presentation, but also in the activation of NF-kappaB by Shigella effector proteins (IpgB2 and OspB) which requires its GEF activity and the activation of RhoA, but does not seem to promote nucleotide exchange activity toward Rac-GTPases, cell cycle regulation, cell motility and polarization, dendritic spine morphology, innate immune response, leukemic cell differentiation, or Ras-GTPases, which was uniquely reported in PubMed:9857026, Activates Rho-GTPases by promoting the exchange of GDP for GTP, flexneri cell invasion
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names ARHGEF2, GEF-H1, GEFH1, Guanine nucleotide exchange factor H1, KIAA0651, LFP40, Microtubule-regulated Rho-GEF, P40, Proliferating cell nucleolar antigen p40, Rho guanine nucleotide exchange factor 2, GEF
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetGEF H1
Short nameGEF H1 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameGEF H1 (Antibody to)
Alternative techniqueantibodies
Identity 15930
Gene SLC2A4RG
Long gene name SLC2A4 regulator
Synonyms GEF HDBP1 Si-1-2 Si-1-2-19
Synonyms name GLUT4 enhancer factor Huntington', s disease gene regulatory region-binding protein 1
Locus 20q13, 33
Discovery year 2001-06-21
GenBank acession AF249267
Entrez gene record 56731
Pubmed identfication 10825161
RefSeq identity NM_020062
Havana BLAST/BLAT OTTHUMG00000032997

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