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Gemin 3/SMA Antibody

Gemin 3/SMA Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameGemin 3/SMA Primary Polyclonal Antibody
Also known asGemin 3/SMA PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenGemin 3/SMA
SpecificityThis is a highly specific antibody against Gemin 3/SMA
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Gemin 3
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen DDX20, DEAD-box protein DP130 and DEAD/H box 20, Gemin3, Gemin3 also interacts with SmB, Gemin3 is a putative RNA helicase and shows ATPase activity, Gemin4, Gemin5 and Gemin6, It associates directly with SMN and is a part of the SMN complex containing Gemin2, It contains the conserved motif Asp-Glu-Ala-Asp (DEAD) characteristic of DEAD-box proteins, It is expressed in B and T cell neuroblastoma-derived cell lines, It is found in both the cytoplasm and the nucleus, SMA is caused by deletion or loss-of-function mutations in the SMN (survival of motor neuron) gene, SmD2 and SmD3, The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing of the nucleus, The nuclear form is concentrated in subnuclear bodies called gems (for Gemini of the coiled bodies), also known as DP103, as well as several spliceosomal snRNP proteins, is a protein product of human chromosome 1p13, kidney and lung, liver, malignant melanoma tumor, normal testis and is expressed in low levels in colon, skeletal muscle, 2, Spinal muscular atrophy (SMA) is an autosomal recessive neurodegenerative disease characterized by loss of motor neurons in the spinal cord
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names Component of gems 3, DDX 20, DDX20, DDX20_HUMAN, DEAD Asp Glu Ala Asp box polypeptide 20, DEAD Asp-Glu-Ala-Asp box polypeptide 20, DEAD box protein 20, DEAD box protein DP 103, DEAD box protein DP103, DEAD-box protein DP103, DEAD/H Asp Glu Ala Asp/His box polypeptide 20, DEAD/H Asp Glu Ala Asp/His box polypeptide 20 103kD, DEAD/H BOX 20, DKFZP434H052, DP 103, DP103, Gemin-3, Gemin3, Probable ATP dependent RNA helicase DDX20, Probable ATP-dependent RNA helicase DDX20, SMN interacting protein, Gemin3
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetGemin 3/SMA
Short nameGemin 3/SMA Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameGemin 3/SMA (Antibody to)
Alternative techniqueantibodies
Identity 11117
Gene SMN1
Long gene name survival of motor neuron 1, telomeric
Synonyms gene SMA@ SMA
Synonyms gene name Kugelberg-Welander disease) , spinal muscular atrophy (Werdnig-Hoffmann disease
Synonyms BCD541 SMNT SMA1 SMA2 SMA3 GEMIN1 TDRD16A
Synonyms name gemin-1 tudor domain containing 16A
Locus 5q13, 2
Discovery year 1996-12-12
GenBank acession U18423
Entrez gene record 6606
Pubmed identfication 7813012
RefSeq identity NM_000344
Classification Tudor domain containing
Havana BLAST/BLAT OTTHUMG00000099361
Locus Specific Databases SMN1 - Spinal Muscular Atrophy (SMA) Leiden Muscular Dystrophy pages ALSOD, the Amyotrophic Lateral Sclerosis Online Genetic Database LRG_676

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