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GFI1B Antibody, Cy5 Conjugated

GFI1B Antibody, Cy5 Conjugated size: 0.1ml 350

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 350
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name Cy5 Conjugated, GFI1B Polyclonal Antibody
CategoryConjugated Primary Antibodies
Conjugation5, Cy5
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenGFI1B
SpecificityThis is a highly specific antibody against GFI1B
ModificationUnmodified
Modification siteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
SourceKLH conjugated synthetic peptide derived from human GFI1B
Gene ID number8328
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
Crossreactivity Mouse, Rat, Human
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background Alters histone methylation by recruiting histone methyltransferase to target genes promoters, Binds to gamma-satellite DNA and to its own promoter, Cooperates with GATA1 to repress target gene transcription, GFI1B silencing in leukemic cell lines markedly increase apoptosis rate, Inhibits down-regulation of MYC and MYB as well as the cyclin-dependent kinase inhibitor CDKN1A/P21WAF1 in IL6-treated myelomonocytic cells, Plays a role in heterochromatin formation, Represses expression of GATA3 in T-cell lymphomas and inhibits GATA1-mediated transcription, Suppresses GATA1-mediated stimulation of GFI1B promoter through protein interaction, Transcriptional repressor or activator depending on both promoter and cell type context, as GATA1 also mediates erythroid GFI1B transcription, auto-repressing its own expression, both GATA1 and GFI1B participate in a feedback regulatory pathway controlling the expression of GFI1B gene in erythroid cells, may regulate cytokine signaling pathways, represses promoter activity of SOCS1 and SOCS3 and thus, such as the apoptosis regulator BCL2L1, Essential proto-oncogenic transcriptional regulator necessary for development and differentiation of erythroid and megakaryocytic lineages
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation Emission625, 650nm/670nm
Synonyms ZNF163B
Properties Cy5 antibodies are excited by the 650-nanometer wave of an argon laser and detected at a 670-nanometer captor, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Gene targetGFI1B Conjugated
Short name Conjugated, GFI1B Antibody
Technique antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
LabelCy5
Alternative name cyanine 5 coupled, GFI1B (Antibody to)
Alternative techniqueantibodies
Identity 4238
Gene GFI1B
Long gene name growth factor independent 1B transcriptional repressor
Synonyms gene name growth factor independent 1B (potential regulator of CDKN1A, translocated in CML)
Locus 9q34, 13
Discovery year 1998-09-17
GenBank acession AF081946
Entrez gene record 8328
Pubmed identfication 9878267
RefSeq identity NM_004188
Classification Zinc fingers C2H2-type SNAG transcriptional repressors
Havana BLAST/BLAT OTTHUMG00000020848
Locus Specific Databases LRG_879

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