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GJB2 Antibody

GJB2 Antibody size: 0.1mg 389

Supplier NJS POLY
Price 389
Size 0.1mg
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
CategoryAntibody
Concentration2ml sterile DI water, 5mg/ml if reconstituted with 0
FormAntigen affinity purified
ConjugationUnconjugated
ClonePolyclonal antibody
Recognised antigenGJB2
Host animalRabbit (Oryctolagus cuniculus)
ClonalityPolyclonal (rabbit origin)
Species reactivity Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens)
Tested applicationsWB
Recommended dilutions5-1ug/ml, Western blot: 0
Notes Titration of the GJB2 antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts
Intented useThis GJB2 antibodyis to be used only for research purposes and not for diagnostics
Uniprot #P29033
PurityAntigen affinity
Description CX26 shares 92, Connexin 26 gene(GJB2) mutation modulates the severity of hearing loss associated with the 1555A-G mitochondrial mutation, GJB2, Gap junctions were first characterized by electron microscopy as regionally specialized structures on plasma membranes of contacting adherent cells, Proteins, The 3-prime untranslated region of the CX26 transcript contains a putative mRNA instability sequence, The deduced 226-amino acid protein has a calculated molecular mass of about 26 kD, These structures were shown to consist of cell-to-cell channels, also known as GAP junction protein, beta2, called connexins, connexin 26(GJB2) is assigned to human chromosome 13q11-q12 , purified from fractions of enriched gap junctions from different tissues differ, 5% identity with rat Cx26, Connexin 26 regulates epidermal barrier and wound remodeling and promotes psoriasiform response, Connexin26(CX26)
ImmunogenAn amino acid sequence from the N-terminus of human GJB2 (MDWGTLQTILGGVNKH) was used as the immunogen for this GJB2 antibody
Storage Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the GJB2 antibody can be stored for up to one month at 4oC, After reconstitution
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°
Gene targetGJB2
Short nameGJB2 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameGJB2 (Antibody to)
Alternative techniqueantibodies
Identity 4284
Gene GJB2
Long gene name gap junction protein beta 2
Synonyms gene DFNB1 DFNA3
Synonyms gene name 26kD (connexin 26) gap junction protein, 26kDa , 26kDa (connexin 26) gap junction protein, beta 2, beta 2, beta 2, gap junction protein
Synonyms CX26 NSRD1
Synonyms name connexin 26
Locus 13q12, 11
Discovery year 1990-02-12
GenBank acession M86849
Entrez gene record 2706
Pubmed identfication 9139825
Classification Gap junction proteins Deafness associated genes
Havana BLAST/BLAT OTTHUMG00000016513
Locus Specific Databases Hereditary Hearing Loss Homepage The Connexin-deafness homepage CCHMC-BMI &, UC Hearing Loss Mutation Database

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