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Glypican 3 Antibody (GPC3)

Glypican 3 Antibody (GPC3) size: 0.08 ml 199

Supplier NJS POLY
Price 199
Size 0.08 ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
CategoryAntibody
Concentration pH 7, with 0, 09% sodium azide, 4, In 1X PBS
FormPurified
ConjugationUnconjugated
ClonePolyclonal antibody
Recognised antigenGlypican 3 (GPC3)
Host animalRabbit (Oryctolagus cuniculus)
ClonalityPolyclonal (rabbit origin)
Species reactivity Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus) , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens)
Tested applications ELISA, IHC, WB
Recommended dilutionsIHC (Paraffin): 1:50-1:100, Western blot: 1:1000
NotesTitration of the Glypican 3 antibody may be required due to differences in protocols and secondary/substrate sensitivity
Intented useThis Glypican 3 antibodyis to be used only for research purposes and not for diagnostics
Uniprot #P51654
PurityPurified
Description Deletion mutations in GPC3 are the cause of Simpson-Golabi-Behmel syndrome (SGBS), Members of the glypican-related integral membrane proteoglycan family contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol (GPI) linkage, SGBS is a condition characterized by pre- and postnatal overgrowth (gigantism) with visceral and skeletal anomalies, These proteins may play a role in the control of cell division, This protein may be involved in the suppression/modulation of growth in the predominantly mesodermal tissues and organs, also known as Simpson dysmorphia syndrome (SDYS), and may play a role in the modulation of IGF2 interactions with its receptor and thereby modulate its function, and tumor predisposition, growth regulation, GPC3 is a cell surface proteoglycan that bears heparan sulfate
ImmunogenA portion of amino acids 21-50 from the human protein was used as the immunogen for this Glypican 3 antibody
Storage Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the Glypican 3 antibody and store frozen at -20 deg
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°
Gene targetGlypican 3 (GPC3)
Short nameGlypican 3 Antibody (GPC3)
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameGlypican 3 (Antibody to) (glypican 3)
Alternative techniqueantibodies
Alternative to gene target DGSX and GTR2-2 and MXR7 and OCI-5 and SDYS and SGB and SGBS and SGBS1, Extracellular, GPC3 and IDBG-630953 and ENSBTAG00000020406 and 615239, GPC3 and IDBG-86754 and ENSG00000147257 and 2719, Gpc3 and IDBG-145213 and ENSMUSG00000055653 and 14734, peptidyl-dipeptidase inhibitor activity, planar cell polarity pathway and biological process, this GO :0001523 and retinoid metabolic process and biological process this GO :0001658 and branching involved in ureteric bud morphogenesis and biological process this GO :0001822 and kidney development and biological process this GO :0005515 and protein binding and molecular function this GO :0005578 and proteinaceous extracellular matrix and cellular component this GO :0005615 and extracellular space and cellular component this GO :0005764 and lysosome and cellular component this GO :0005796 and this GO lgi lumen and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0005975 and carbohydrate metabolic process and biological process this GO :0006024 and glycosaminoglycan biosynthetic process and biological process this GO :0006027 and glycosaminoglycan catabolic process and biological process this GO :0007603 and phototransduction, this GO :0005515: protein binding, this GO :0005515: protein binding and also this GO :0043395: heparan sulfate proteoglycan binding and also this GO :0060422: peptidyl-dipeptidase inhibitor activity, this GO :0043395: heparan sulfate proteoglycan binding, this GO :0060422: peptidyl-dipeptidase inhibitor activity, visible light and biological process this GO :0008285 and negative regulation of cell proliferation and biological process this GO :0009653 and anatomical structure morphogenesis and biological process this GO :0009887 and organ morphogenesis and biological process this GO :0009948 and anterior/posterior axis specification and biological process this GO :0010171 and body morphogenesis and biological process this GO :0010466 and negative regulation of peptidase activity and biological process this GO :0016020 and membrane and cellular component this GO :0030203 and glycosaminoglycan metabolic process and biological process this GO :0030204 and chondroitin sulfate metabolic process and biological process this GO :0030282 and bone mineralization and biological process this GO :0030316 and osteoclast differentiation and biological process this GO :0030324 and lung development and biological process this GO :0030513 and positive regulation of BMP signaling pathway and biological process this GO :0035116 and embryonic hindlimb morphogenesis and biological process this GO :0040008 and regulation of growth and biological process this GO :0043202 and lysosomal lumen and cellular component this GO :0043395 and heparan sulfate proteoglycan binding and molecular function this GO :0044281 and small molecule metabolic process and biological process this GO :0045732 and positive regulation of protein catabolic process and biological process this GO :0045807 and positive regulation of endocytosis and biological process this GO :0045879 and negative regulation of smoothened signaling pathway and biological process this GO :0045880 and positive regulation of smoothened signaling pathway and biological process this GO :0045926 and negative regulation of growth and biological process this GO :0046326 and positive regulation of glucose import and biological process this GO :0046658 and anchored component of plasma membrane and cellular component this GO :0050680 and negative regulation of epithelial cell proliferation and biological process this GO :0060422 and peptidyl-dipeptidase inhibitor activity and molecular function this GO :0060976 and coronary vasculature development and biological process this GO :0070062 and extracellular vesicular exosome and cellular component this GO :0072111 and cell proliferation involved in kidney development and biological process this GO :0072138 and mesenchymal cell proliferation involved in ureteric bud development and biological process this GO :0072180 and mesonephric duct morphogenesis and biological process this GO :0072203 and cell proliferation involved in metanephros development and biological process this GO :0090090 and negative regulation of canonical Wnt signaling pathway and biological process this GO :2000096 and positive regulation of Wnt receptor signaling pathway, glypican 3
Identity 4451
Gene GPC3
Long gene name glypican 3
Synonyms gene SDYS
Synonyms OCI-5 SGBS SGBS1 SGB DGSX
Synonyms name glypican proteoglycan 3
Locus Xq26, 2
Discovery year 1996-08-08
GenBank acession L47125
Entrez gene record 2719
Pubmed identfication 8589713 9787072
RefSeq identity NM_004484
Classification Glypicans
Havana BLAST/BLAT OTTHUMG00000022448
Locus Specific Databases LRG_505

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