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GRB10/14 Antibody, ALEXA FLUOR 488

GRB10/14 Antibody, ALEXA FLUOR 488 size: 100ul 332

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES
Price 332
Size 100ul
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name ALEXA FLUOR 488 Conjugated, GRB10/14 Polyclonal Antibody
Also known asAnti-GRB10/14 PAb ALEXA FLUOR 488
CategoryConjugated Primary Antibodies
Conjugated with 488, ALEXA FLUOR®
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenGRB10/14
SpecificityThis is a highly specific antibody against GRB10/14
ModificationUnmodified
Modification SiteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen range574-594/594
Subcellular locationCytoplasm
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human GRB10
Gene ID Number2887, 2888
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
Crossreactivity Mouse, Rat, Human
Cross-reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the antigen Binds to, Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation, Delays and reduces AKT1 phosphorylation in response to insulin stimulation, GRB14 is a potent inhibitor of insulin-stimulated MAPK3 phosphorylation, May inhibit NEDD4-mediated degradation of KDR/VEGFR-2, May play a role in mediating insulin-stimulated ubiquitination of INSR, Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6, Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, Positive regulator of the KDR/VEGFR-2 signaling pathway, Recruits NEDD4 to IGF1R, The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation, activated receptors tyrosine kinases, and suppress signals from, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors, increased internalization and degradation by both the proteasomal and lysosomal pathways, leading to IGF1R ubiquitination, leading to proteasomal degradation, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal, Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways
PurificationPurified by Protein A
Storage conditions 50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA
Excitation emission499nm/519nm
Properties ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), Also Alexa Fluor 488 is pH stable, As a result of this photo stability, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is distinguished in the FL1 of a FACS-Calibur or FACScan, has a very high photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry, yet the GRB10/14 Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate
ConjugationAlexa Fluor
Gene targetGRB10/14
Short nameGRB10/14 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
LabelALEXA FLUOR 488
Alternative name ALEXA FLUOR 488, GRB10/14 (Antibody to)
Alternative techniqueantibodies
Identity 4564
Gene GRB10
Long gene name growth factor receptor bound protein 10
Synonyms gene name growth factor receptor-bound protein 10
Locus 7p12, 1
Discovery year 1996-05-30
Entrez gene record 2887
RefSeq identity NM_005311
Classification Pleckstrin homology domain containing SH2 domain containing
Havana BLAST/BLAT OTTHUMG00000150622
Locus Specific Databases LRG_1032

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