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HAS2 Antibody

HAS2 Antibody size: 0.08 ml 199

Supplier NJS POLY
Price 199
Size 0.08 ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
CategoryAntibody
Concentration pH 7, with 0, 09% sodium azide, 4, In 1X PBS
FormAntigen affinity purified
ConjugationUnconjugated
ClonePolyclonal antibody
Recognised antigenHAS2
Host animalRabbit (Oryctolagus cuniculus)
ClonalityPolyclonal (rabbit origin)
Species reactivity Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus) , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens)
Tested applications ELISA, FACS, IHC, WB
Recommended dilutionsFlow Cytometry: 1:10-1:50, IHC (Paraffin): 1:25-1:100, Western blot: 1:1000
NotesTitration of the HAS2 antibody may be required due to differences in protocols and secondary/substrate sensitivity
Intented useThis HAS2 antibodyis to be used only for research purposes and not for diagnostics
Uniprot #Q92819
PurityAntigen affinity
Description Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis, HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts, HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, HAS2 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, In addition, It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds, It serves a variety of functions, and human and murine hyaluronan synthase 1, and is a constituent of the extracellular matrix, and its amino acid sequence shows significant homology to glycosaminoglycan synthetase (DG42) from Xenopus laevis, and overexpression of HA receptors has been correlated with tumor metastasis, and provision of a matrix through which cells can migrate, and the chains are extruded through pore-like structures into the extracellular space, including space filling, lubrication of joints, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals
ImmunogenA portion of amino acids 138-166 from the human protein was used as the immunogen for this HAS2 antibody
Storage Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the HAS2 antibody and store frozen at -20 deg
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°
Gene targetHAS2
Short nameHAS2 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameHAS2 (Antibody to)
Alternative techniqueantibodies
Identity 4819
Gene HAS2
Long gene name hyaluronan synthase 2
Locus 8q24, 13
Discovery year 1996-10-18
GenBank acession U54804
Entrez gene record 3037
Pubmed identfication 9169154
RefSeq identity NM_005328
Classification Glycosyltransferase family 2
Havana BLAST/BLAT OTTHUMG00000164953

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