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HER-2/NEU Antibody

HER-2/NEU Antibody size: 0.08 ml 199

Supplier NJS POLY
Price 199
Size 0.08 ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
CategoryAntibody
Concentration09% sodium azide, 4 with 0, In 1X PBS pH 7
FormAntigen affinity purified
ConjugationUnconjugated
ClonePolyclonal antibody
Recognised antigenHER-2/NEU
Host animalRabbit (Oryctolagus cuniculus)
ClonalityPolyclonal (rabbit origin)
Species reactivity Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens)
Tested applications ELISA, WB
Recommended dilutionsWestern blot: 1:1000
NotesTitration of the HER-2/NEU antibody may be required due to differences in protocols and secondary/substrate sensitivity
Intented useThis HER-2/NEU antibodyis to be used only for research purposes and not for diagnostics
Uniprot #P04626
PurityAntigen affinity
Description Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, Alternative splicing results in several additional transcript variants, Amplification and/or overexpression of this gene has been reported in numerous cancers, However, Ile654/Ile655, This protein has no ligand binding domain of its own and therefore cannot bind growth factors, including breast and ovarian tumors, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, shown here, some encoding different isoforms and others that have not been fully characterized, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase, with the most common allele, This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases
ImmunogenA portion of amino acids 1151-1179 from the human protein was used as the immunogen for this HER-2/NEU antibody
Storage Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the HER-2/NEU antibody and store frozen at -20 deg
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°
Gene targetHER-2/NEU
Short nameHER-2/NEU Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameHER-2/NEU (Antibody to)
Alternative techniqueantibodies
Identity 3430
Gene ERBB2
Long gene name erb-b2 receptor tyrosine kinase 2
Synonyms gene NGL
Synonyms gene name v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog) v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2
Synonyms NEU HER-2 CD340 HER2
Synonyms name neuro/glioblastoma derived oncogene homolog human epidermal growth factor receptor 2
Locus 17q12
Discovery year 2001-06-22
GenBank acession X03363
Entrez gene record 2064
RefSeq identity NM_004448
Classification CD molecules Minor histocompatibility antigens Erb-b2 receptor tyrosine kinases
Havana BLAST/BLAT OTTHUMG00000179300
Locus Specific Databases LRG_724

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