hHR23b Antibody

hHR23b Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES

Price 263

Size 0.1ml

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Long name	hHR23b Primary Polyclonal Antibody
Also known as	hHR23b PAb
Category	Primary Antibodies
Conjugation	Unconjugated
Target Antigen	hHR23b
Specificity	This is a highly specific antibody against hHR23b
Modification(s)	None
Modification site(s)	Unmodified antibody
Clonality	Polyclonal antibody
Clone number	Polyclonal antibody
Concentration	1ug per 1ul
Immunogen range	10-60/409
Subcellular location	Nucleus, Cytoplasm
Source	This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human hHR23b
Gene ID number	5887
Swiss Prot	P54727
Tested Applications	IF(IHC-P), IHC-P, WB
Recommended dilutions	IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity	Mouse, Rat, Human
Cross reactive species details	not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen	Binds to polyubiquitin chains, Cooperatively with CETN2 appears to stabilize XPC, Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation, In vitro, Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair, Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex, May play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome, May protect XPC from proteasomal degradation, Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome, RPA and the TFIIH complex, The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, The orientation of XPC complex binding appears to be crucial for inducing a productive NER, XPA, XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery, is part of the pre-incision (or initial recognition) complex, it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts, mismatched bubbles or single-stranded overhangs, the XPC:RAD23B dimer is sufficient to initiate NER, Multiubiquitin chain receptor involved in modulation of proteasomal degradation
Purification method	This antibody was purified via Protein A
Storage conditions	50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names	HHR23B, HR23B, RAD23B, UV excision repair protein RAD23 homolog B, XP-C repair-complementing complex 58 kDa protein, P58
Properties	C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene target	hHR23b
Short name	hHR23b Antibody
Technique	antibodies against human proteins, antibodies for, Antibody
Alternative name	hHR23b (Antibody to)
Alternative technique	antibodies
Identity	9813
Gene	RAD23B
Long gene name	RAD23 homolog B, nucleotide excision repair protein
Synonyms gene name	RAD23 (S, cerevisiae) , cerevisiae) homolog B RAD23 homolog B (S
Synonyms	HHR23B P58 HR23B
Synonyms name	XP-C repair complementing protein XP-C repair complementing complex 58 kDa
Locus	9q31, 2
Discovery year	1994-07-20
Entrez gene record	5887
Pubmed identfication	7851894 8168482
RefSeq identity	NM_002874
Classification	Nucleotide excision repair
Havana BLAST/BLAT	OTTHUMG00000020446

hHR23b Antibody

hHR23b Antibody size: 0.1ml 263

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