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HIF3 alpha Antibody, Biotin Conjugated

HIF3 alpha Antibody, Biotin Conjugated size: 0.1ml 333

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 333
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name Biotin Conjugated, HIF3 alpha Polyclonal Antibody
CategoryConjugated Primary Antibodies
ConjugationBiotinylated
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenH3 alpha
SpecificityThis is a highly specific antibody against H3 alpha
ModificationUnmodified
Modification siteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen_range161-200/669
Subcellular location Nucleus, Cytoplasm
SourceKLH conjugated synthetic peptide derived from human HIF3 alpha
Gene ID number64344
Swiss ProtQ9Y2N7
Tested applications IHC-P, WB
Recommended dilutions IHC-P(1:100-500), WB(1:100-1000)
Crossreactivity Mouse, Rat, Human
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background Binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters, Conversely, Functions as an inhibitor of angiogenesis in the cornea (By similarity), Hypoxia induces down-regulation of isoform 4, Isoform 4 attenuates the binding of HIF1A to hypoxia-responsive elements (HRE), Isoform 4 has a dominant-negative function of inactivating HIF1A-mediated transcription, Isoform 4 may be a negative regulator of hypoxia-inducible gene expression in the kidney and may be involved in renal tumorigenesis, Suppresses hypoxia-inducible expression of HIF1A and EPAS1, The complex HIF3A-ARNT activates the transcription of reporter genes driven by HRE, leading to activation of HIF1A in hypoxia, the expression of isoform 4 increases and thereby secure an inhibition of HIF1A activity, thus inhibiting HRE-driven transcription, upon restoring normoxia, Involved in adaptive response to hypoxia
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation EmissionN/A
Synonyms Basic-helix-loop-helix-PAS protein MOP7, Class E basic helix-loop-helix protein 17, HIF-3-alpha, HIF-3A, HIF3-alpha, HIF3-alpha-1, HIF3A, Hypoxia-inducible factor 3-alpha, Inhibitory PAS domain protein, MOP7, Member of PAS protein 7, PAS domain-containing protein 7, PASD7, bHLHe17, IPAS
Properties Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Gene targetHIF3 alpha Conjugated
Short name Conjugated, HIF3 alpha Antibody
Technique antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
LabelBiotin
Alternative name biotinilated coupled, HIF3 a (Antibody to)
Alternative techniqueantibodies

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