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HIP12 Antibody, ALEXA FLUOR 647

HIP12 Antibody, ALEXA FLUOR 647 size: 100ul 332

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES
Price 332
Size 100ul
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name ALEXA FLUOR 647 Conjugated, HIP12 Polyclonal Antibody
Also known asAnti-HIP12 PAb ALEXA FLUOR 647
CategoryConjugated Primary Antibodies
Conjugated with 647, ALEXA FLUOR®
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenHIP12
SpecificityThis is a highly specific antibody against HIP12
ModificationUnmodified
Modification SiteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human HIP1R/HIP12/HIP3
Gene ID Number9026
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
Crossreactivity Mouse, Rat, Human
Cross-reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the antigen HIP1, HIP1 contains an endocytic multidomain protein with a C-terminal Actin-binding domain, HIP1 is ubiquitously expressed in different brain regions at low levels and exhibits nearly identical subcellular fractionation as huntingtin, HIP1 may be involved in vesicle trafficking, HIP12 differs from HIP1 in its pattern of expression at both the mRNA and protein level, HIP12 does not directly interact with huntingtin but can interact with HIP1, HIP12 is a non-proapoptotic member of the HIP gene family that is expressed in the brain and shares a similar subcellular distribution pattern with HIP1, However, The HIP1 gene locates to the human chromosome 7q11, The huntingtin-HIP1 interaction is restricted to the brain and is inversely correlated to the polyglutamine length in the huntingtin, a central coiled-coil forming region and an N-terminal ENTH domain, a membrane-associated protein, binds specifically to the N-terminus of human huntingtin, greater than 35 repeats, huntingtin, in the HD gene product, suggesting that loss of normal huntingtin-HIP1 interaction may compromise the membrane-cytoskeletal integrity in the brain, the structural integrity of HIP1 is crucial for maintenance of normal vesicle size in vivo, 23, Huntington disease is associated with the expansion of a polyglutamine tract
PurificationPurified by Protein A
Storage conditions 50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA
Excitation emission650nm/665nm
Synonyms KIAA0655 HIP3 HIP12 FLJ14000 ILWEQ
Properties ALEXA FLUOR made this Alexa Fluor 633 conjugate that can be used in multi-color flow cytometry with instruments equipped with a second red laser or red diode, ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 633 is a practical alternative to APC as well as Cy5, Bioss Primary Conjugated Antibodies, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is detected in the FL4 detector of the core's upgraded 2-laser FACScans, Like other Alexa Fluor dyes, exhibits uncommon photo stability, making it an ideal choice for fluorescent microscopy, the HIP12 Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate
Conjugation ALEXA FLUOR 647, Alexa Fluor
Gene targetHIP12
Short nameHIP12 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
LabelALEXA FLUOR 647
Alternative name ALEXA FLUOR 647, HIP12 (Antibody to)
Alternative techniqueantibodies
Identity 18415
Gene HIP1R
Long gene name huntingtin interacting protein 1 related
Locus 12q24, 31
Discovery year 2006-01-23
GenBank acession AB013384
Entrez gene record 9026
Pubmed identfication 16415883
RefSeq identity NM_003959
Havana BLAST/BLAT OTTHUMG00000168765

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