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HLA-C Antibody

HLA-C Antibody size: 0.1mg 406

Supplier NJS POLY
Price 406
Size 0.1mg
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
CategoryAntibody
Concentration2ml sterile DI water, 5mg/ml if reconstituted with 0
FormAntigen affinity purified
ConjugationUnconjugated
ClonePolyclonal antibody
Recognised antigenHLA-C
Host animalRabbit (Oryctolagus cuniculus)
ClonalityPolyclonal (rabbit origin)
Species reactivity Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens)
Tested applications ICC, IHC-P, WB
Recommended dilutions1-0, 5-1ug/ml, 5-1ug/ml, 5ug/ml, ICC: 0, IHC (Paraffin): 0, Western blot: 0
NotesOptimal dilution of the HLA-C antibody should be determined by the researcher
Intented useThis HLA-C antibodyis to be used only for research purposes and not for diagnostics
Uniprot #U5YBW8
PurityAntigen affinity
Description Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen, Exon one encodes the leader peptide, Over one hundred HLA-C alleles have been described, Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule, The heavy chain is anchored in the membrane, The heavy chain is approximately 45 kDa and its gene contains 8 exons, They are expressed in nearly all cells, This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin), Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation, and exons 6 and 7 encode the cytoplasmic tail, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, HLA-C belongs to the HLA class I heavy chain paralogues
ImmunogenAmino acids EYWDRETQKYKRQAQADRVNLRKLR of human HLA-C were used as the immunogen for the HLA-C antibody
Storage Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the HLA-C antibody may be kept for up to one month refrigerated at +4 degrees C, After reconstitution, For long-term
Localization membranous, Cytoplasmic
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°
Gene targetHLA-C
Short nameHLA-C Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative name C (Antibody to), class I, major histocompatibility complex
Alternative techniqueantibodies
Alternative to gene target C, Cell surfaces, D6S204 and HLA-JY3 and HLC-C and PSORS1, HLA-C and IDBG-77290 and ENSG00000204525 and 3107, TAP-dependent and biological process this GO :0002480 and antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent and biological process this GO :0005515 and protein binding and molecular function this GO :0005783 and endoplasmic reticulum and cellular component this GO :0005794 and this GO lgi apparatus and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006955 and immune response and biological process this GO :0009986 and cell surface and cellular component this GO :0012507 and ER to this GO lgi transport vesicle membrane and cellular component this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0016032 and viral process and biological process this GO :0019221 and cytokine-mediated signaling pathway and biological process this GO :0019882 and antigen processing and presentation and biological process this GO :0030670 and pha this GO cytic vesicle membrane and cellular component this GO :0031901 and early endosome membrane and cellular component this GO :0042590 and antigen processing and presentation of exogenous peptide antigen via MHC class I and biological process this GO :0042605 and peptide antigen binding and molecular function this GO :0042612 and MHC class I protein complex and cellular component this GO :0045087 and innate immune response and biological process this GO :0050776 and regulation of immune response and biological process this GO :0060333 and interferon-gamma-mediated signaling pathway and biological process this GO :0060337 and type I interferon signaling pathway and biological process this GO :0070062 and extracellular vesicular exosome and cellular component this GO :0071556 and integral component of lumenal side of endoplasmic reticulum membrane and cellular component, class I, peptide antigen binding, this GO :0000139 and this GO lgi membrane and cellular component this GO :0001916 and positive regulation of T cell mediated cytotoxicity and biological process this GO :0002474 and antigen processing and presentation of peptide antigen via MHC class I and biological process this GO :0002479 and antigen processing and presentation of exogenous peptide antigen via MHC class I, this GO :0005515: protein binding, this GO :0005515: protein binding and also this GO :0042605: peptide antigen binding, this GO :0042605: peptide antigen binding, major histocompatibility complex
Identity 4933
Gene HLA-C
Long gene name C , class I, major histocompatibility complex
Synonyms gene HLA-JY3 D6S204 PSORS1
Synonyms gene name psoriasis susceptibility 1
Locus 6p21, 33
Discovery year 1986-01-01
GenBank acession M11886
Entrez gene record 3107
Pubmed identfication 3863816 16642438
RefSeq identity NM_002117
Classification C1-set domain containing Histocompatibility complex
Havana BLAST/BLAT OTTHUMG00000031154
Locus Specific Databases IMGT/HLA Database

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