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HLA-DRA (302CT2.3.2) Monoclonal Antibody

HLA-DRA (302CT2.3.2) Monoclonal Antibody size: 0.1ml 328

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 328
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name2) Monoclonal Antibody, 3, HLA-DRA (302CT2
Also known as2) Monoclonal Antibody, 3, HLA-DRA (302CT2
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenHLA-DRA
SpecificityThis is a highly specific antibody against HLA-DRA
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityMonoclonal
Clone number2, 3, 302CT2
SourceThis HLA-DRA antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 48-75 amino acids from human HLA-DRA
Gene ID number3122
Swiss ProtP01903
Tested ApplicationsWB
Recommended dilutionsWB(1:500~16000)
Cross reactivityHuman
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, Autophagy is also a source of endogenous peptides, CD74 undergoes a sequential degradation by various proteases, Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound, In addition to APCs, Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, The MHC II molecule bound to a peptide is then transported to the cell membrane surface, The peptide binding cleft accommodates peptides of 10-30 residues, The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released, To produce a MHC class II molecule that presents an antigen, and for this reason this antigen presentation pathway is usually referred to as exogenous, autophagosomes constitutively fuse with MHC class II loading compartments, exogenous antigens must compete with those derived from endogenous components, express MHC class II molecules and CD74 and act as APCs, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide), other cells of the gastrointestinal tract, such as epithelial cells, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer, where they are processed by lysosomal proteases and other hydrolases, which is an unusual trait of the GI tract, Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells
Purification method09% (W/V) sodium azide, Mouse monoclonal antibody supplied in crude ascites with 0
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names DR alpha chain, HLA class II histocompatibility antigen, HLA-DRA, MHC class II antigen DRA, HLA-DRA1
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
About Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones
Gene target2) Monoclonal, 3, HLA-DRA (302CT2
Short name2) Monoclonal Antibody, 3, HLA-DRA (302CT2
Technique Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody
Alternative name DR a (302CT2, class II, 2) monoclonal (Antibody to), 3, major histocompatibility aggregate
Alternative techniqueantibodies
Alternative to gene target BOLA-DRA and IDBG-632808 and ENSBTAG00000010645 and 506214, Cell surfaces, DR alpha, HLA-DRA and IDBG-80796 and ENSG00000204287 and 3122, HLA-DRA1 and MLRW, class II, peptide antigen binding, this GO :0000139 and this GO lgi membrane and cellular component this GO :0002503 and peptide antigen assembly with MHC class II protein complex and biological process this GO :0002504 and antigen processing and presentation of peptide or polysaccharide antigen via MHC class II and biological process this GO :0002506 and polysaccharide assembly with MHC class II protein complex and biological process this GO :0005515 and protein binding and molecular function this GO :0005764 and lysosome and cellular component this GO :0005765 and lysosomal membrane and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0006955 and immune response and biological process this GO :0009986 and cell surface and cellular component this GO :0012507 and ER to this GO lgi transport vesicle membrane and cellular component this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0019221 and cytokine-mediated signaling pathway and biological process this GO :0019882 and antigen processing and presentation and biological process this GO :0019886 and antigen processing and presentation of exogenous peptide antigen via MHC class II and biological process this GO :0023026 and MHC class II protein complex binding and molecular function this GO :0030658 and transport vesicle membrane and cellular component this GO :0030666 and endocytic vesicle membrane and cellular component this GO :0030669 and clathrin-coated endocytic vesicle membrane and cellular component this GO :0031295 and T cell costimulation and biological process this GO :0031902 and late endosome membrane and cellular component this GO :0032395 and MHC class II receptor activity and molecular function this GO :0032588 and trans- this GO lgi network membrane and cellular component this GO :0042605 and peptide antigen binding and molecular function this GO :0042613 and MHC class II protein complex and cellular component this GO :0050852 and T cell receptor signaling pathway and biological process this GO :0050890 and cognition and biological process this GO :0060333 and interferon-gamma-mediated signaling pathway and biological process this GO :0070062 and extracellular vesicular exosome and cellular component this GO :0071556 and integral component of lumenal side of endoplasmic reticulum membrane and cellular component, this GO :0005515: protein binding, this GO :0005515: protein binding and also this GO :0023026: MHC class II protein complex binding and also this GO :0032395: MHC class II receptor activity and also this GO :0042605: peptide antigen binding, this GO :0023026: MHC class II protein complex binding, this GO :0032395: MHC class II receptor activity, this GO :0042605: peptide antigen binding, major histocompatibility complex
Identity 4947
Gene HLA-DRA
Long gene name DR alpha , class II, major histocompatibility complex
Synonyms gene HLA-DRA1
Locus 6p21, 32
Discovery year 2001-06-22
Entrez gene record 3122
RefSeq identity NM_019111
Classification C1-set domain containing Histocompatibility complex
Havana BLAST/BLAT OTTHUMG00000031269
Locus Specific Databases IMGT/HLA Database

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