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Involucrin

Involucrin size: 100ug 354

Supplier MBS MONO
Price 354
Size 100ug
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Also known asInvolucrin
Other names Involucrin, N/A, involucrin, involucrin, involucrin
CategoryAntibodies
SubcategoryMnoclonal antibodies
Gene nameIVL
Gene name synonimsN/A
Other gene names IVL, N/A, N/A, IVL
ClonalityMonoclonal
Immunoglobulin isotype kappa, IgG1
CloneSY5
Host organismMouse (Mus musculus)
Species reactivity Does not react with Mouse (Mus musculus), Dog, Due to limited knowledge and inability for testing each and every species, Gorilla, Owl monkey, Pig, the reactivity of the antibody may extend to other species which are not listed hereby, Human (Homo sapiens)
Specificity and cross-reactivity 66kDa in dog, In Western blotting of cultured human keratinocytes, In normal epidermis, Involucrin expression is altered in pathological conditions: in psoriasis and other benign epidermal hyperplasias, Involucrin is expressed in a range of stratified squamous epithelia, It stains the involucrin in a variety of sizes: 170kDa in MCF-7 cells, Its epitope maps between codon 421-568 of human involucrin, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, This particular antibody might cross react with speacies outside of the listed ones, a doublet of ~115kDa and 150kDa in gorilla and owl monkey, all cells that have left the basal layer express it, and a doublet of 105kDa in pig, and in keratinocyte cultures, and is reduced in severe dysplasias of the larynx and cervix, expression is abnormal in squamous cell carcinomas and premalignant lesions, identified as involucrin, including the cornea, involucrin expression begins closer to the basal layer than normal, it is first expressed in the upper spinous layers, this MAb reacts with a 120kDa protein, which lacks a distinct cornified layer, It recognizes a protein of 66kDa-170kDa
Purification methodN/A
Form/AppearanceN/A
ConcentrationN/A
Storage and shipping Antibody is stable for 24 months, Temperature variations in the range of 1 to 7 degrees Celsius are tolerable, We recommend NOT to freeze the antibody, Store the antibody at +4C
Tested applications: Flow Cytometry (FC/FACS), Immunofluorescence (IF), Immunohistology (IH), Immunoprecipitation (IP), Western Blot (WB), ELISA (EIA)
Gene targetInvolucrin
Short nameInvolucrin
Alternative nameInvolucrin
Identity 6187
Gene IVL
Long gene name involucrin
Locus 1q21, 3
Discovery year 1986-01-01
GenBank acession BC046391
Entrez gene record 3713
Pubmed identfication 2873896
RefSeq identity NM_005547
Classification Cornified envelope precursor family
Havana BLAST/BLAT OTTHUMG00000012451

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