| Long name | IRS1(Ser789) Primary Polyclonal Antibody |
| Also known as | IRS1(Ser789) PAb |
| Category | Primary Antibodies |
| Conjugation | Unconjugated |
| Target Antigen | IRS1 Ser789 |
| Specificity | This is a highly specific antibody against IRS1 Ser789 |
| Modification(s) | Phosphorylation |
| Modification site(s) | Ser789 |
| Clonality | Polyclonal antibody |
| Clone number | Polyclonal antibody |
| Concentration | 1ug per 1ul |
| Source | KLH conjugated synthetic phosphopeptide derived from mouse IRS1 around the phosphorylation site of Ser789 |
| Gene ID number | 16367 |
| Tested Applications | IF(IHC-P), IHC-P, WB |
| Recommended dilutions | IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity | Mouse, Rat, Human |
| Cross reactive species details | not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen | 2, 3 and 4, IRS1 has also been shown to be constitutively activated in cancers such as breast cancer, Serine/threonine phosphorylation of IRS1 has been demonstrated to be a negative regulator of insulin signaling and is responsible for its degradation, To date there have been four subtypes identified: IRS1, Wilm's tumors, although IRS1 degradation pathways are not well understood, and adrenal cortical carcinomas, apoptosis and insulin signal transduction, cell growth, cell transformation, such as glucose homeostasis, thus making IRS1 phosphorylation and subsequent degradation an attractive therapeutic target, with IRS1 being widely expressed, Insulin receptor substrates (IRS) are responsible for several insulin related activities |
| Purification method | This antibody was purified via Protein A |
| Storage conditions | 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names | HIRS 1, HIRS1, IRS 1, IRS-1, IRS1, IRS1Ser789, IRS1_HUMAN, Insulin Receptor Substrate 1, OTTHUMP00000164234, p-IRS1 |
| Properties | C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target | IRS1(Ser789) |
| Short name | IRS1(Ser789) Antibody |
| Technique | antibodies against human proteins, antibodies for, Antibody |
| Alternative name | insulin receptor substrate 1(Ser789) (Antibody to) |
| Alternative technique | antibodies |
| Alternative to gene target | HIRS-1, IRS1 and IDBG-647770 and ENSBTAG00000021308 and 538598, IRS1 and IDBG-82407 and ENSG00000169047 and 3667, Irs1 and IDBG-173589 and ENSMUSG00000055980 and 16367, nuclei, phosphatidylinositol 3-kinase binding, this GO :0002053 and positive regulation of mesenchymal cell proliferation and biological process this GO :0004871 and signal transducer activity and molecular function this GO :0005068 and transmembrane receptor protein tyrosine kinase adaptor activity and molecular function this GO :0005080 and protein kinase C binding and molecular function this GO :0005158 and insulin receptor binding and molecular function this GO :0005159 and insulin-like growth factor receptor binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005899 and insulin receptor complex and cellular component this GO :0005901 and caveola and cellular component this GO :0007165 and signal transduction and biological process this GO :0007173 and epidermal growth factor receptor signaling pathway and biological process this GO :0008284 and positive regulation of cell proliferation and biological process this GO :0008286 and insulin receptor signaling pathway and biological process this GO :0008543 and fibroblast growth factor receptor signaling pathway and biological process this GO :0010468 and regulation of gene expression and biological process this GO :0010907 and positive regulation of glucose metabolic process and biological process this GO :0014065 and phosphatidylinositol 3-kinase signaling and biological process this GO :0016042 and lipid catabolic process and biological process this GO :0019901 and protein kinase binding and molecular function this GO :0030335 and positive regulation of cell migration and biological process this GO :0030879 and mammary gland development and biological process this GO :0032000 and positive regulation of fatty acid beta-oxidation and biological process this GO :0032868 and response to insulin and biological process this GO :0032869 and cellular response to insulin stimulus and biological process this GO :0034504 and protein localization to nucleus and biological process this GO :0036064 and ciliary basal body and cellular component this GO :0038095 and Fc-epsilon receptor signaling pathway and biological process this GO :0042169 and SH2 domain binding and molecular function this GO :0042593 and glucose homeostasis and biological process this GO :0043231 and intracellular membrane-bounded organelle and cellular component this GO :0043434 and response to peptide hormone and biological process this GO :0043491 and protein kinase B signaling and biological process this GO :0043548 and phosphatidylinositol 3-kinase binding and molecular function this GO :0043552 and positive regulation of phosphatidylinositol 3-kinase activity and biological process this GO :0045087 and innate immune response and biological process this GO :0045725 and positive regulation of glycogen biosynthetic process and biological process this GO :0046326 and positive regulation of glucose import and biological process this GO :0046627 and negative regulation of insulin receptor signaling pathway and biological process this GO :0046628 and positive regulation of insulin receptor signaling pathway and biological process this GO :0046676 and negative regulation of insulin secretion and biological process this GO :0048009 and insulin-like growth factor receptor signaling pathway and biological process this GO :0048011 and neurotrophin TRK receptor signaling pathway and biological process this GO :0048015 and phosphatidylinositol-mediated signaling and biological process this GO :0060397 and JAK-STAT cascade involved in growth hormone signaling pathway and biological process this GO :2001275 and positive regulation of glucose import in response to insulin stimulus and biological process, this GO :0004871: signal transducer activity, this GO :0004871: signal transducer activity and also this GO :0005068: transmembrane receptor protein tyrosine kinase adaptor activity and also this GO :0005080: protein kinase C binding and also this GO :0005158: insulin receptor binding and also this GO :0005159: insulin-like growth factor receptor binding and also this GO :0005515: protein binding and also this GO :0019901: protein kinase binding and also this GO :0042169: SH2 domain binding and also this GO :0043548: phosphatidylinositol 3-kinase binding, this GO :0005068: transmembrane receptor protein tyrosine kinase adaptor activity, this GO :0005080: protein kinase C binding, this GO :0005158: insulin receptor binding, this GO :0005159: insulin-like growth factor receptor binding, this GO :0005515: protein binding, this GO :0019901: protein kinase binding, this GO :0042169: SH2 domain binding, this GO :0043548: phosphatidylinositol 3-kinase binding, insulin receptor substrate 1 |
| Identity | 6125 |
| Gene | IRS1 |
| Long gene name | insulin receptor substrate 1 |
| Synonyms | HIRS-1 |
| Locus | 2q36, 3 |
| Discovery year | 1992-08-24 |
| Entrez gene record | 3667 |
| Pubmed identfication | 1648180 |
| RefSeq identity | NM_005544 |
| Classification | Pleckstrin homology domain containing |
| Havana BLAST/BLAT | OTTHUMG00000133179 |
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