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LEO1 Antibody, HRP Conjugated

LEO1 Antibody, HRP Conjugated size: 0.1ml 350

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 350
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name HRP Conjugated, LEO1 Polyclonal Antibody
CategoryConjugated Primary Antibodies
ConjugationHRP Conjugated
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenLEO1
SpecificityThis is a highly specific antibody against LEO1
ModificationUnmodified
Modification siteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen_range500-550/666
Subcellular locationNucleus
SourceKLH conjugated synthetic peptide derived from human LEO1
Gene ID number123169
Swiss ProtQ8WVC0
Tested applications IHC-P, WB
Recommended dilutions IHC-P(1:100-500), WB(1:100-1000)
Crossreactivity Mouse, Rat, Human
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background Connects PAF1C to Wnt signaling, In case of infection by influenza A strain H3N2, Involved in polyadenylation of mRNA precursors, PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, PAF1C associates with viral NS1 protein, PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1, PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3), PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors, PAF1C is required for transcription of Hox and Wnt target genes, PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1), UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1, it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL, thereby regulating gene transcription, Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% Gentamicin, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation EmissionN/A
Properties Also monoclonal HRP conjugates are often used for Western Blot, HRP conjugates are often primary rabbit polyclonal antibodies couples to the , found in the roots of , (HRP), C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°, enzyme , horseradish, horseradish peroxidase 
Gene targetLEO1 Conjugated
Short name Conjugated, LEO1 Antibody
Technique antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
LabelHRP
Alternative name horseradish peroxidase coupled, LEO1 (Antibody to)
Alternative techniqueantibodies
Identity 30401
Gene LEO1
Long gene name LEO1 homolog, Paf1/RNA polymerase II complex component
Synonyms gene name Leo1, Paf1/RNA polymerase II complex component, cerevisiae) , homolog (S
Locus 15q21, 2
Discovery year 2005-07-20
GenBank acession AY302186
Entrez gene record 123169
Pubmed identfication 15632063 24038468
RefSeq identity NM_138792
Classification Paf1/RNA polymerase II complex
Havana BLAST/BLAT OTTHUMG00000131843

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