| Long name | Cy5, 5 Conjugated, LRP5(Thr1492) Polyclonal Antibody |
| Category | Conjugated Primary Antibodies |
| Conjugation | Cy5, 5, 5, Cy5 |
| Host Organism | Rabbit (Oryctolagus cuniculus) |
| Target Antigen | LRP5 Thr1492 |
| Specificity | This is a highly specific antibody against LRP5 Thr1492 |
| Modification | Phosphorylation |
| Modification site | Thr1492 |
| Clonality | Polyclonal |
| Clone | Polyclonal antibody |
| Concentration | 1ug per 1ul |
| Immunogen_range | 1470-1520/1615 |
| Subcellular location | Cytoplasm |
| Source | KLH conjugated synthetic phosphopeptide derived from human LRP5 around the phosphorylation site of Thr1492 |
| Gene ID number | 4041 |
| Swiss Prot | O75197 |
| Tested applications | IF(IHC-P) |
| Recommended dilutions | IF(IHC-P)(1:50-200) |
| Crossreactivity | Mouse, Rat, Human |
| Crossreactive species details | not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background | Appears be required for postnatal control of vascular regression in the eye, Cell-surface coreceptor of Wnt/beta-catenin signaling, Required for posterior patterning of the epiblast during gastrulation, The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin, which plays a pivotal role in bone formation, Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes |
| Purification method | This antibody was purified via Protein A |
| Storage conditions | 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Excitation Emission | 675nm/694nm |
| Synonyms | LR3 BMND1 HBM OPS OPTA1 VBCH2 EVR4 |
| Properties | Cy5 antibodies are excited by the 650-nanometer wave of an argon laser and detected at a 670-nanometer captor, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Conjugated | These antibodies are excite for emission at 678nm and detected at a 694 , nm wavelengths |
| Gene target | LRP5(Thr1492) Conjugated |
| Short name | Conjugated, LRP5(Thr1492) Antibody |
| Technique | antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label | 5, Cy5 |
| Alternative name | cyanine 5, 5 coupled, low density lipoprotein receptor-related protein 5(Thr1492) (Antibody to) |
| Alternative technique | antibodies |
| Alternative to gene target | BMND1 and EVR1 and EVR4 and HBM and LR3 and LRP-5 and LRP7 and OPPG and OPS and OPTA1 and VBCH2, DNA-templated and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0046849 and bone remodeling and biological process this GO :0046850 and regulation of bone remodeling and biological process this GO :0048539 and bone marrow development and biological process this GO :0048596 and embryonic camera-type eye morphogenesis and biological process this GO :0051091 and positive regulation of sequence-specific DNA binding transcription factor activity and biological process this GO :0060033 and anatomical structure regression and biological process this GO :0060042 and retina morphogenesis in camera-type eye and biological process this GO :0060059 and embryonic retina morphogenesis in camera-type eye and biological process this GO :0060070 and canonical Wnt signaling pathway and biological process this GO :0060348 and bone development and biological process this GO :0060349 and bone morphogenesis and biological process this GO :0060444 and branching involved in mammary gland duct morphogenesis and biological process this GO :0060603 and mammary gland duct morphogenesis and biological process this GO :0060612 and adipose tissue development and biological process this GO :0060764 and cell-cell signaling involved in mammary gland development and biological process this GO :0060828 and regulation of canonical Wnt signaling pathway and biological process this GO :0061178 and regulation of insulin secretion involved in cellular response to glucose stimulus and biological process this GO :0061299 and retina vasculature morphogenesis in camera-type eye and biological process this GO :0061304 and retinal blood vessel morphogenesis and biological process this GO :0071901 and negative regulation of protein serine/threonine kinase activity and biological process this GO :1902262 and apoptotic process involved in patterning of blood vessels and biological process, LRP5 and IDBG-61383 and ENSG00000162337 and 4041, LRP5 and IDBG-644859 and ENSBTAG00000005903 and 534450, Lrp5 and IDBG-128306 and ENSMUSG00000024913 and 16973, Plasma membranes, Wnt-activated receptor activity, this GO :0001702 and gastrulation with mouth forming second and biological process this GO :0001944 and vasculature development and biological process this GO :0002053 and positive regulation of mesenchymal cell proliferation and biological process this GO :0002076 and osteoblast development and biological process this GO :0005515 and protein binding and molecular function this GO :0005739 and mitochondrion and cellular component this GO :0005783 and endoplasmic reticulum and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006007 and glucose catabolic process and biological process this GO :0006897 and endocytosis and biological process this GO :0008203 and cholesterol metabolic process and biological process this GO :0008217 and regulation of blood pressure and biological process this GO :0008284 and positive regulation of cell proliferation and biological process this GO :0009952 and anterior/posterior pattern specification and biological process this GO :0015026 and coreceptor activity and molecular function this GO :0016021 and integral component of membrane and cellular component this GO :0016055 and Wnt signaling pathway and biological process this GO :0017147 and Wnt-protein binding and molecular function this GO :0030326 and embryonic limb morphogenesis and biological process this GO :0033690 and positive regulation of osteoblast proliferation and biological process this GO :0035019 and somatic stem cell maintenance and biological process this GO :0035108 and limb morphogenesis and biological process this GO :0035426 and extracellular matrix-cell signaling and biological process this GO :0042074 and cell migration involved in gastrulation and biological process this GO :0042632 and cholesterol homeostasis and biological process this GO :0042733 and embryonic digit morphogenesis and biological process this GO :0042813 and Wnt-activated receptor activity and molecular function this GO :0042981 and regulation of apoptotic process and biological process this GO :0043235 and receptor complex and cellular component this GO :0043434 and response to peptide hormone and biological process this GO :0044332 and Wnt signaling pathway involved in dorsal/ventral axis specification and biological process this GO :0045600 and positive regulation of fat cell differentiation and biological process this GO :0045668 and negative regulation of osteoblast differentiation and biological process this GO :0045840 and positive regulation of mitosis and biological process this GO :0045893 and positive regulation of transcription, this GO :0005515: protein binding, this GO :0005515: protein binding and also this GO :0015026: coreceptor activity and also this GO :0017147: Wnt-protein binding and also this GO :0042813: Wnt-activated receptor activity, this GO :0015026: coreceptor activity, this GO :0017147: Wnt-protein binding, this GO :0042813: Wnt-activated receptor activity, low density lipoprotein receptor-related protein 5 |
| Identity | 6697 |
| Gene | LRP5 |
| Long gene name | LDL receptor related protein 5 |
| Synonyms gene | LRP7 OPPG EVR1 |
| Synonyms gene name | osteoporosis pseudoglioma syndrome exudative vitreoretinopathy 1 low density lipoprotein receptor-related protein 5 |
| Locus | 11q13, 2 |
| Discovery year | 1998-04-07 |
| GenBank acession | AF064548 |
| Entrez gene record | 4041 |
| Pubmed identfication | 9714764 10049586 |
| RefSeq identity | NM_002335 |
| Classification | Low density lipoprotein receptors |
| Havana BLAST/BLAT | OTTHUMG00000167570 |
| Locus Specific Databases | LOVD - Leiden Open Variation Database |
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