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MAPKAPK5(Thr182) Antibody, ALEXA FLUOR 350

MAPKAPK5(Thr182) Antibody, ALEXA FLUOR 350 size: 100ul 350

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES
Price 350
Size 100ul
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name ALEXA FLUOR 350 Conjugated, MAPKAPK5(Thr182) Polyclonal Antibody
Also known asAnti-MAPKAPK5 Thr182 PAb ALEXA FLUOR 350
CategoryConjugated Primary Antibodies
Conjugated with 350, ALEXA FLUOR®
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenMAPKAPK5 Thr182
SpecificityThis is a highly specific antibody against MAPKAPK5 Thr182
ModificationPhosphorylation
Modification SiteThr182
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen range160-210/473
Subcellular location Nucleus, Cytoplasm
SourceKLH conjugated synthetic phosphopeptide derived from human MAPKAPK5 around the phosphorylation site of Thr182
Gene ID Number8550
Swiss ProtQ8IW41
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
Crossreactivity Mouse, Human
Cross-reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the antigen 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent MYC translation, Acts as a negative regulator of mTORC1 signaling by mediating phosphorylation and inhibition of RHEB, Acts as a tumor suppressor by mediating Ras-induced senescence and phosphorylating p53/TP53, ERK3/MAPK6, ERK3/MAPK6 (or ERK4/MAPK4) is phosphorylated and then mediates phosphorylation and activation of MAPKAPK5, ERK4/MAPK4, HSP27/HSPB1, Involved in post-transcriptional regulation of MYC by mediating phosphorylation of FOXO3: phosphorylation of FOXO3 leads to promote nuclear localization of FOXO3, Mediates phosphorylation of HSP27/HSPB1 in response to PKA/PRKACA stimulation, Part of the atypical MAPK signaling via its interaction with ERK3/MAPK6 or ERK4/MAPK4: the precise role of the complex formed with ERK3/MAPK6 or ERK4/MAPK4 is still unclear, Phosphorylates FOXO3, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPK (ERK3/MAPK6 or ERK4/MAPK4), enabling expression of miR-34b and miR-34c, inducing F-actin rearrangement, p53/TP53 and RHEB, which in turn phosphorylates ERK3/MAPK6 (or ERK4/MAPK4), Tumor suppressor serine/threonine-protein kinase involved in mTORC1 signaling and post-transcriptional regulation
PurificationPurified by Protein A
Storage conditions 50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA
Excitation emission343nm/442nm
Synonyms PRAK
Properties ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 350 conjugates can be used in multi-color flow cytometry with FACS's equipped with a second red laser or red diode, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate
Conjugation ALEXA FLUOR 350, Alexa Fluor
Gene targetMAPKAPK5(Thr182)
Short nameMAPKAPK5(Thr182) Antibody
Technique antibodies against human proteins, antibodies for, Antibody
LabelALEXA FLUOR 350
Alternative name ALEXA FLUOR 350, MAPKAPK5(Thr182) (Antibody to)
Alternative techniqueantibodies
Identity 6889
Gene MAPKAPK5
Long gene name mitogen-activated protein kinase-activated protein kinase 5
Locus 12q24, 12-q24, 13
Discovery year 1999-03-26
GenBank acession AF032437
Entrez gene record 8550
Pubmed identfication 9628874
RefSeq identity NM_139078
Classification Mitogen-activated protein kinase-activated protein kinases
Havana BLAST/BLAT OTTHUMG00000169605

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